106 results
* To estimate the prevalence of hyposalivation and xerostomia in pediatric cancer survivors treated with different cancer regimens (e.g., H&N RT, TBI, CT, or those who developed cGVHD following allogeneic stem cell transplantation).* To…
The main objective of this study is to evaluate whether earlier establishment of Critical View of Safety can be obtained during laparoscopic cholecystectomy, by applying NIRF laparoscopic imaging as an adjunct to conventional laparoscopic imaging…
The objectives of this open-label extension*safety monitoring (OLE-SM) study are as follows: Part 1 (Open-Label Extension; OLE) • To assess the long-term safety and efficacy of etrolizumab in patients eligible for Part 1 (OLE) Part 2 (Safety…
The primary objective of this prospective open label study is to assess the ability of vedolizumab to promote clinical, endoscopic and histological remission in patients with active UC in an 'early' and a 'late' disease…
Objective: The objective of the prospective NAFLD cohort study with biobank is: 1. In a cross-sectional design (a) to determine which factors are associated with the presence of NASH in a population of NAFLD patients and (b) to identify and validate…
The aim of this study is to perform a randomized comparison between ESD and EMR in large (>20 mm) distal non-pedunculated polyps in a Western population. We aim to compare both procedures with regard to recurrence rates and radical (R0)…
That patients who have had clinical response or clinical remission after use with Risankizumab can continue using Risankizumab. Also long term safety of Risankizumab will be assessed in patients who were diagnosed with moderate to severe Crohn'…
Determine the efficacy and safety (using objective response rate) of tremelimumab in patients with advanced solid tumors (UBC, PDAC, TNBC).
To assess the efficacy and safety of 2 dose levels of NTRA-2112 on intestinal malabsorption in preterm infants as compared to placebo.The sub-study aims to determine whether NTRA-2112 in own mother's milk, donor human milk or preterm formula…
Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…
The aim of this study is to compare gut-directed hypnotherapy with standard medical treatment in children and adolescents with chronic idiopathic nausea or nausea due to functional dyspepsia. We will examine the effect of these treatments on…
The primary objective of this study is to test the hypothesis that treatment with LY3074828 is superior to placebo in inducing clinical remission at Week 12 in subjects with moderate to severe ulcerative colitis (UC).The secondary objectives are:-To…
Induction Phase (IP)* To independently evaluate the efficacy of etrolizumab dose regimens compared with placebo in inducing clinical remission and endoscopic improvement at the end of the Induction Phase (Week 14)Maintenance Phase (MP)* To…
Induction PeriodPrimary:Demonstrate the efficacy of RPC1063 versus placebo on induction of clinical remission.Secondary:* Demonstrate the efficacy of RPC1063 versus placebo on induction of clinical response* Demonstrate the efficacy of RPC1063…
The primary aim of this study is to develop a physiologically-based PK model for three different anti-TNF agents describing the relationship between dose and concentration in three physiological compartments in patients with moderate to severe…
The POINTER trial investigates whether immediate treatment with catheter drainage is superior to the current practice of postponed catheter drainage within the step-up approach in patients with infected necrotizing pancreatitis.
The aim of our study is to investigate the effect of sirolimus on the progression of intestinal adenomas in patients with FAP and to assess the safety of this treatment.
To study the efficacy of end-ischemic DHOPE in reducing the incidence of NAS within six months after controlled DCD (Maastricht category III) liver transplantation.
To explore regions of brain and brainstem activation in healthy volunteers during abdominal pain or discomfort after chemical nociceptive stimulation of the duodenum with capsaicin. In the future, we aim to perform the same study in IBS-/FD-patients…
The objective of this study is to compare the efficacy of Infliximab-biosimilar to Infliximab-innovator and to demonstrate its noninferiority up to 30 weeks, in patients with ulcerative colitis or Crohn*s disease in remission under treatment with…