47 results
The purpose of this project is to perform a randomized trial comparing BARRX ablation with endoscopic surveillance for patients with a Barrett*s esophagus containing low-grade dysplasia. This study will also assess the effect of RFA ablation in…
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
To examine the effect of surgical trauma on mucosal perfusion, intestinal epithelial damage, the inflammatory response and potentially sepsis, following surgery remote to the abdomen in adults, children and neonates,
Primary: To assess the effects of visilizumab on the safety of subsequent salvage therapies in subjects who experienced disease progression in a previous visilizumab study and subsequently received salvage therapy (see Definitions).Subjects will be…
The primary efficacy endpoint is treatment success in the therapy for mild to moderate Crohn*s disease with fisultas defined by: - A reduction of at least 50% in the number of draining fistulas at both week 4 and week 8
The objective of this study is to compare TNE with conventional upper GI endoscopy in detecting esophageal mucosal abnormalities, effectiviness of barrier for microorganisme and patients experience with both techniques.
1. To invest the prevalence of bacterial overgrowth in the elderly who undergo an diagnostic gastroscopy.2. After investigating the number of microorganisms in the aspirate the probable correlation will be established between the complaints of the…
Primary objectives1. What is the pulmonary function and exercise tolerance in children born with esophageal atresia at the age of 8-18 years (group I), determined by spirometry, measurement of lung volumes and a maximal exercise test. 2. What is the…
What is the normal stool frequency among premature and full term neonates?What is the normal colour of stools of the neonate?What is the normal consistency and amount of stools?What is the normal colonic transit time of premature and full term born…
To asses the effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants
Investigating the safety of adalimumab when administered in subjects with Crohn*s Disease as well as evaulating the efficacy of adalimumab for the induction and maintenance of clinical remission and fistula closure in subjects with moderate to…
Enteral Nutritional strategies compared to reduce postoperative ileus after major colorectal surgery
The main objective of this clinical survey is to improve the nutritional status of patients undergoing major rectal surgery, thereby aiming to reduce postoperative ileus using the Bengmark a self-migrating nasojejunal tube and early enteral…
The purpose of this study is to find answers for the following questions:1. Is BARRX ablation a good alternative to step-wise radical endoscopic resection for patients with a Barrett*s esophagus with high-grade dysplasia or early cancer in terms of…
JNJ-2607019 is an investigational drug being developed for gastroesophageal reflux disease (GERD) to reduce the complaints of abdominal pain and heartburn in people with this disease. JNJ-26070109 inhibits the gastrin receptor in the stomach. The…
Aim:With this study we would like to prove that also in humans, NOD2 signaling inhibits the TLR2-mediated immune response.
to study the relation between esophageal circular contractions and chest pain episode(s) in treated patients with achalasia by using 24-hour esophageal manometry combined with pH-metry/impedance
The current project aims to confirm this defective production of IL-8 and explore the possible underlying defect by examining the functionality of the major signal transduction pathways involved in IL-8 production.
This study is conducted to evaluate a novel method of augmenting a weak Lower Esophageal Sphincter (LES) with a magnetic esophgeal sphincter device.
The purpose of this project is to evaluate the combination of ER using the multi-band mucosectomy technique and RFA (HALO360/HALO90) for treatment of Barrett*s esophagus with HGD or early cancer. This will be a multi-centre European study including…
To compare colonic stenting followed by elective surgery with emergency surgery for the management of acute left-sided malignant colonic obstruction in terms of health-related quality of life, morbidity and mortality.