62 results
investigate the relationship between il28b and apolipoproteine E genotype and response to interferon
We aim to develop a novel immunotherapy based on donor-derived exosomes that specifically suppress the anti-donor T-cell response after organ transplantation, while leaving overall immunity intact. The therapy targets both the direct and the…
The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
The primary objective of this pilot study is to evaluate the effects of 6 months of recombinant human IGF-I (rhIGF-I) treatment on the body composition.The secondary objective is to assess the effects of the treatment on the liver function,…
The primary objective is to elucidate the question whether historic HBV viral load (in samples taken from 1989 * 1996 during pregnancy) is associated with the risk of HBV-related cirrhosis or mortality in a cohort of non-Asian individuals with…
To determine if LA is a familial disease. To identify germline mutations in HNF-1 alpha, ß-catenin and CYP1B1 genes in LA patients. To screen first degree relatives of patients diagnosed with liver adenomatosis for the presence of liver adenomas and…
To assess the diagnostic accuracy of MR Elastography in detecting and monitoring different degrees of liver fibrosis compared to FibroScan and histopathology in patients with suspected chronic viral liver disease and non-alcoholic fatty liver…
To demonstrate and compare expression of CCL25 and CCR9+ lymphocytes in peripheral blood and colon of PSC-, PSC/IBD-, IBD-, gastroenteritis patients and controls.
In this study we will examine the short-term effects of a single bout of physical activity on liver fat content. Research question: What are the short- term effects of a single bout of moderate physical activity on liver fat content?
Primary:To estimate the difference in SVR rates between T12/PR24 and T12/PR48 treatment regimens in subjects who achieve eRVR.Secondary:To evaluate the safety of telaprevir in combination with Peg-IFN-alfa-2a and RBV in treatment-naïve subjects with…
The primary objectives of this trial are the following:- to determine the dose dependency of the antiviral effect of TMC435350 during 1 week ofmonotherapy in treatment-naïve HCV-infected subjects;- to determine the dose dependency of the antiviral…
Validation and quantification of 3.0 Tesla 1H *MRS for the assessment of hepatic steatosis in patients with non alcoholic fatty liver disease and patients chronically infected with hepatitis C. Is there a close correlation between the 1H *MRS…
Assessment of hepatic HSPG*s in NASH associated dyslipidemia in 8 subjects with DM2 associated NASH (insulin resistant, n=8) vs NASH in FHBL (non insulin resistant, n=8) and control subjects (hemochromatosis, n=8)
To determine the 1 year sustainability of the effects of a lifestyle intervention on NAFLD in severely obese children and determine the relation between long term changes in liver steatosis and other clinical and biochemical parameters. Finally, to…
Hypothetically, in patients with PBC or PSC the FGF-19 production or -response could be altered. The goal of this research is to study the FGF19 production after a standardized oral fat challenge and the effect of this FGF19 production on bile acid…
Objective: Primary objectives: To screen TCR/BCR repertoires in patients with primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC) and IgG4-associated cholangitis (IAC).Secondary objectives: To determine the influence of disease…
To determine whether different MR-based imaging techniques and FibroScan can be used for the purpose of identifying and monitoring Gaucher Disease patients at high risk of developing disease related liver complications.
To demonstrate completeness of occlusion of the segmental portal branches after unilateral PVE by intraoperative portography. A secondary aim is to assess the perfusion of the liver after PVE on microvascular level by O2C and ICG clearance; and to…
efficacy of lanreotide LAR in controling total liver volume in patients with hepatic cysts as a result of ADPKD or PCLD
To calculate the repeatability and reproducibility of MRE stiffness measurements in the liver on a voxel-by-voxel basis.