19 results
The purpose of this study is compare a tablet formulation of PXL770 to the capsule formulation of PXL770. It will be investigated how quickly and to what extent PXL770 in each formulation is absorbed and eliminated from the body. To limit the…
To assess the safety and effect of edoxaban in Chil-Pugh B cirrhosis.
Phenotypical and Pathophysiological Characterization of Patients with Alcohol-related Liver Disease.
The primary objective of the study is to identify, develop and validate non-invasive biomarkers for the assessment of alcohol use in patients with ALD. This by determining ethylglucuronide in hair, nail and urine in this population. By validating…
To investigate if currently employed ultrasound measurements for diagnosing a portal vein anastomosis stenosis remain reliable when children are not fasting
The identification of a new gene(s) that causes autosomal dominant polycystic liver disease.
The primary objective of this study is to demonstrate the clinical utility of the addition of per oral cholangioscopy (POCS) to standard ERCP with brushing cytology for diagnosis and early detection of cholangiocarcinoma in patients diagnosed with…
The primary objective of this study is to examine to what extent hepatic glycogen is decreased after a prolonged overnight fast in healthy volunteers with a normal weight and low liver fat percentage.
The purpose of this study is to investigate how quickly and to what extent PF-06835919 is absorbed and eliminated from the body.PF-06835919 will be labelled with Carbon-14 (14C) and is thus radioactive. In this way, PF-06835919 can be traced in…
The aim of this study is to prospectively assess the benefits and effectiveness of non-complex gallstone clearancefluoroscopy / radiation-free direct solitary cholangioscopy (DSC) comparing the SpyGlass * system to non-complex biliary stone…
Primary objective:To assess the effect of 12 weeks of GSK3228836 on serum hepatitis B virus surface antigen (HBsAg) levels in participants with CHBSecondaryEfficacy: To assess sustainability of serum HBsAg loss by GSK3228836 for up to 24 weeks off-…
To study the safety and efficacy of prolonged (>2 hours) end-ischemic DHOPE, by assessing the occurrence of (serious) adverse events during machine perfusion and within 30 days after liver transplantation.
Primary Objective:The primary objective is to evaluate the efficacy of repeated once-daily doses of odevixibat versus placebo in children with biliary atresia (BA) post Kasai hepatoportoenterostomy(HPE) based native liver survival (NLS) of up to 104…
Primary objectivesThe trial has two parts, a part 1 and a part 2, with distinctive objectives and endpoints.Part 1 of the trial: To demonstrate that treatment with semaglutide s.c. improves liver histology compared to placebo in subjects with NASH…
* To demonstrate the clinical utility of POCS in cadaveric donor or live donor liver transplantation patients referred for endoscopic retrograde cholangiopancreatography (ERCP) in the setting of a clinical suspicion of post-liver transplant bile…
Primary Objective: Assess if the structure, composition and/or barrier function of the biliary HCO3- umbrella is intrinsically altered in cholangioids and liver biopsies derived from fibrosing cholangiopathy subjects compared to non-fibrosing…
The primary objective is:to demonstrate the efficacy of 2 infusions (intravenous [i.v.]) of HepaStem at 1.0 million of cells/kg body weight (BW) (7 days apart) on the overall survival proportion at 90 days post first infusion.The secondary…
Primary:To evaluate the efficacy of 3 doses of RhuDex vs placebo for the treatment of PBC in patients with an inadequate response to UDCA.Secondary:• To identify efficacious RhuDex dose(s) for the treatment of PBC for further evaluation in phase III…
To proof feasibility and safety of direct SEMS placement for palliative treatment of perihilar cholangiocarcinoma.
To assess the safety and tolerability of PLN 74809 in participants with PSC and suspected liver fibrosis