21 results
To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.
Based on the gaps in our knowledge (as stated above), we have formulated the following objectives:- To quantify the degree of hepatic fat accumulation and fibrosis in patients with HFI. - To gain more insight in the mechanism leading to NAFLD in…
The primary aim of this project is to discover new cellular (non-invasive) biomarkers for the diagnosis and monitoring of immune-mediated liver diseases. Secondly we aim to effectively differentiate AIH from DILI and NAFL from NASH.
In Part 1, a single dose of EYP001a or placebo (same formulation but without the active ingredient EYP001a) will be administered and a total of 6 dose levels of EYP001a will be investigated. The purpose of Part 1 is to investigate how safe EYP001a…
Primary Objective: To assess whether the current use and dosing in cirrhosis of anticoagulation is as effective in inhibiting ex vivo thrombin generation compared to the treatment of patients with competent liver function
To investigate FGF19 signalling and metabolic and functional consequences of a disturbed enterohepatic cycle in patients with obstructive cholestasis
Primary objective: to investigate the incidence of IAC in patients resected for presumed PHC.Secundary objectives:- Evaluation of the diagnostic accuracy of histological criteria for IAC compared to IgG4 qPCR test- Evaluation of disease activity by…
Evaluate effects of one month alcohol abstinence in a healthy population of moderate drinkers.
Primairy objective: To determine the diagnostic accuracy of MRI for the (differential) diagnosis of GB polyps and the differentiation between true and pseudo polyps in patients with suspected GB polyp(s) on previous imaging modality (TAUS) by using…
This study is designed to provide evidence regarding the prophylactic use of UDCA in preventing symptomatic gallstone disease after RYGB and Sleeve Gastrectomy.
To compare the sensitivity of ERCP brush cytology between standard RX cytology brush and Inifinity brush in patients with pancreatobiliary strictures suspicious for malignancy.
This study is primarily set up to investigate the safety and feasibility of IRE for the treatment of unresectable, locally advanced or nodal metastasized PHC. The efficacy of IRE will also be studied.
The main objective of this study is to determine whether a single neoadjuvant gift of anti-EGFR mAb, administered 48 hours prior to local treatment of colorectal liver metastases, reduces the number of CTCs. Secondary endpoints are determination of…
Primary Objective: To assess the ex-vivo anticoagulant potency of Edoxaban in patients with Child Pugh A/B cirrhosis, by means of percentual changes in ex-vivo thrombin generation from baseline compared to steady state. These results will be…
To assess the safety and tolerability profile of LJN452 and to determine the early hepatic response to different doses of LJN452 in patients with phenotypic non-alcoholic steatohepatitis (NASH). Data from this study will be used to support further…
To identify disease-causing gene mutations in a Dutch cohort of PSC patients who were diagnosed before the age of 13.
The primary objective of this study is to identify non-invasive tools (e.g. biomarkers and imaging) to diagnose patients with NASH. The secondary objective is to identify an association between markers and disease severity and to investigate the…
To study the feasibility, and reliability of ex-situ viability testing of high risk donor livers using DHOPE, rewarming and NMP, by assessing graft survival at 3 months after transplantation.
Primary objective:To compare the effect of semaglutide subcutaneous (s.c.) once daily versus placebo on histological resolution of non-alcoholic steatohepatitis (NASH). Secondary efficacy objectivesTo investigate the dose-response relationship of…
To assess the efficacy and safety of mycophenolate mofetil as induction therapy in patients with treatment naive autoimmune hepatitis.