18 results
To investigate the use of a temporary peginterferon alpha-2a add-on strategy during entecavir therapy in patients with HBeAg-positive chronic hepatitis B by comparing the efficacy of this regimen versus entecavir monotherapy.To evaluate the long-…
This study will focus on the positive and negative psychological consequences of organ transplantation in Dutch organ transplant recipients. The study will describe on posttraumatic stress and posttraumatic growth after organ transplantation, their…
To answer 3 questions: What is the incidence of drug induced liver disorders in a population during ordinarily circumstances?Which drugs are associated with an increased risk of liver disorders?Are there genetic mutations which could explain (…
Objevtive of the study is to analyze a European cohort of patients with INCIPH based on scientific analyses of clinical, laboratory and morphological data prospectively collected. HIV patients with known splenomagaly will be invited for abdominal…
The most important objectives of this study:1) examine the bacterial translocation as a consequence of elevated intestinal permeability in the morbid obese compared to controls, and to proove this is causes an inflammatory status predisposing IR/…
The aim of this study is to investigate the effect of ATP8B1 carrier on hearing in human.
To investigate sustained HBeAg response to peg-interferon alfa-2b in chronic HBeAg-positive hepatitis B patients who are pretreated with nucleos(t)ide analogues, thereby lowering viral loadDetermine the effect of PEG-IFNa on NK cell function and…
To demonstrate and compare expression of CCL25 and CCR9+ lymphocytes in peripheral blood and colon of PSC-, PSC/IBD-, IBD-, gastroenteritis patients and controls.
This study aims to investigate neurodevelopment in primary school children surviving biliary atresia when compared to a healthy reference group. Second aim is to identify prognostic factors associated with a worse outcome in these children.
To set up a cohort of HIV infected MSM who subsequently acquired HCV infection with a known date of HCV seroconversion to study:- determinants/risk factors for acquiring HCV in HIV infected MSM- the outcome of HCV treatment in this population- the…
To assess the diagnostic accuracy of MR Elastography in detecting and monitoring different degrees of liver fibrosis compared to FibroScan and histopathology in patients with suspected chronic viral liver disease and non-alcoholic fatty liver…
To examine the genetic contribution to the mechanism of lapaquistat acetate induced hepatic abnormalities.
The aim of this study is to investigate what proportion of HBeAg negative, inactive carriers of the hepatitis B virus with low (< 20,000 IU/mL) load will lose HBsAg when treated with nucleot(s)ide analogue/Peg-IFN combination therapy.
Assessment of hepatic HSPG*s in NASH associated dyslipidemia in 8 subjects with DM2 associated NASH (insulin resistant, n=8) vs NASH in FHBL (non insulin resistant, n=8) and control subjects (hemochromatosis, n=8)
We want to evaluate the relation between intestinal integrity and the constitution of the intestinal microbiota, versus inflammatory and insulin resistance in patients with morbid obesity and patients with a normal weight.
To determine the 1 year sustainability of the effects of a lifestyle intervention on NAFLD in severely obese children and determine the relation between long term changes in liver steatosis and other clinical and biochemical parameters. Finally, to…
To investigate whether the expression of renal water and sodium transporters in urinary exosomes is different in compensated versus decompensated liver and heart disease.
Assess hepatotoxicity of long-term azathioprine and 6-mercaptopurine use in IBD-patients as compared with a cohort of long-term 6TG users