20 results
Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…
To evaluate the prevalence of gastrointestinal ischemia in patients with acute and chronic non-cirrhotic, non-malignant PVT.
Aim of this study is to assess the value of cholangioscopic directed biopsies versus brush cytology in differentiating between malignant and benign biliary strictures. Determination of tumor markers to improve early diagnosis of malignant biliary…
To determine if LA is a familial disease. To identify germline mutations in HNF-1 alpha, ß-catenin and CYP1B1 genes in LA patients. To screen first degree relatives of patients diagnosed with liver adenomatosis for the presence of liver adenomas and…
Pruritus is a frequent and debilitating symptom in patients with Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis and other cholestatic liver diseases. Aim is to assess the effect of Colesevelam on cholestatic pruritus.
The primary objective is to study the effect of a 16-week treatment with a PPAR-* agonist versus placebo on effectiveness of subsequent standard treatment with PEG-IFN and RBV, measured as SVR, in previously non-responders or relapsers with CHC…
A proof-of-principle study to test whether an environmental factor, i.e. here IFNα treatment, induces epigenetic alterations of certain genes in blood lymphocytes and whether these alterations correlate with the severity of psychiatric symptoms, i.e…
Primary:Assessment of the effect of preventive versus on demand nutritional advice and a nutritional supplement (a daily energy- and protein-rich evening snack) on weight loss of patients receiving standard antiviral therapy with PEG-interferon in…
efficacy of lanreotide LAR in controling total liver volume in patients with hepatic cysts as a result of ADPKD or PCLD
To eassess the effect of a switch in immunosuppressive regimen and dosing regimen on renal function, blood pressure and laboratory parameters.To assess the effect on renal function, blood pressue and laboratory parameters of a switc from tacrolimus…
In patients with primary biliary cirrhosis (PBC) taking UDCA, to assess the effects of INT-747 on: Primary: - Alkaline phosphatase (AP) levels - SafetySecondary: - Hepatocellular injury and liver function - Disease-specific and general health…
To register the feasibility of treatment with peginterferon and ribavirin for chronic hepatitis C in (previous) substance users and other difficult to treat patients within the Project Active Testing.
The primary objective is to demonstrate the superior efficacy of telaprevir in combination withPeg-IFN alfa-2a and RBV compared to standard treatment in subjects with chronic HCVgenotype 1 infection who failed prior treatment with Peg-IFN plus RBV.…
To establish platelet function during orthotopic liver transplantation.
Primary:To estimate the difference in SVR rates between T12/PR24 and T12/PR48 treatment regimens in subjects who achieve eRVR.Secondary:To evaluate the safety of telaprevir in combination with Peg-IFN-alfa-2a and RBV in treatment-naïve subjects with…
To compare the efficacy and tolerability of a combination therapy with ursodeoxycholic acid (12-16 mg/kg body weight plus budesonide (9mg/d) vs. ursodeoxycholic acid (12-16 mg/kg BW/d) plus placebo in the treatment of PBC. To study safety and…
The primary objective is to study if non-diabetic patients with biopsy-proven NASH have higher hepatic FDG-uptake as compared to non-diabetic patients with biopsy-proven non-inflammatory steatosis?Secondary Objectives are (1) to study the…
in this project we will compare conventional 10fg plastic endoprosthesis with similar stents covalently coated with heparin
In this study we will examine the short-term effects of a single bout of physical activity on liver fat content. Research question: What are the short- term effects of a single bout of moderate physical activity on liver fat content?
In the present study the effects of the colonic administration of butyrate on portal, hepatic, mesenteric venous and arterial SCFA concentrations will be studied in patients undergoing major upper abdominal surgery. The aim is to clarify the…