130 results
Our overall objective is to better understand the role of regulatory B cells in disease pathogenesis and to better predict disease flares in order to individualize treatment.
To determinate the efficacy and safety of golimumab in patients with psoriatic arthritis in daily clinical practice prospectively. In addition, the effect of treatment with golimumab on the lipid profile will be monitored during this study and…
The objectives of this initiative are:1. To establish the disease oriented biobank; processing and storage of blood and CSF specimens and health information of MS patients (which may include health records, family history, lifestyle and genetic…
to investigate functional characteristics of immune cells from MS patients, including migratory capacity, inflammasome activity and Breg cell function and compare these to healthy control subjects 2) to assess possible differences with regard to the…
The aim of this randomized controlled trial is to determine the affect of screening on the Gastrointestinal symptoms (GIS) and Health Related Quality of Life (HRQL) in asymptomatic first degree relatives of CD patients. On the basis of the results,…
The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…
by improving the understanding of the relationship of CRD to clinical expressions of allergic disease in children, this study aims at generating data that can improve the development of tools that will help the primary or secondary care practitioner…
Primary objective: To evaluate the influence of pSS on sexual function, as measured by the female sexual function index (FSFI), in comparison to a healthy control group. Secundary objective: To evaluate the influence of pSS on subdomains of sexual…
Has the supplementation of oligosaccharides in the first year of life an effect on the incidence of atopic diseases and infections from the 5th until the 7th year of life in healthy children
To study the validity and usefulness of three immunological assays to improve knowledge on the course and diagnosis of sesame seed allergy in sesame seed allergic patients with proven anaphylaxis. In the first place, the CAP inhibition assay is used…
We hypothesize that an electronic nose can discriminate between the exhaled breath of patients with established pulmonary sarcoidosis from healthy controls Secondly, we hypothesize that an electronic nose can discriminate between different stages of…
1. Validate and adjust the current classification criteria for systemic vasculitis2. Develop and validate new diagnostic criteria for systemic vasculitis
The aim of this study is to provide evidence that the electronic nose is able to discriminate between the groups that are mentioned above in a cross-sectional study.
Primary endpoint:- Successful desensitization for Mesalazine in ulcerative colitis patients with a presumed history of intolerance for Mesalazine. Secondary endpoint:- To investigate if a presumed intolerance for Mesalazine may be reproducible in a…
To determine the replication history of DS-B-lymphocytes by KRECs in relation to somatic hypermutation.
Primary Objective: To investigate the presence of periodontitis in ACPA and or RF positive patients with arthralgia*s.Secondary Objective: to unravel the role of the cellular immune response in ACPA positive persons with arthralgia*s who are at risk…
The objective of this research is to study the effectiveness of the online zelfmanagementtraining ReumaUitgedaagd! by young adults with Juvenile Idiopathic Arthritis (JIA) who are treated on the transition outpatient clinic of the departments…
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Primairy objective:* To assess whether a poor vitamin D status in RRMS patients is negatively associated with cognitive performance in neuropsychological tests (information processing speed and working memory) and with measures of cognitive (dys)…
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…