95 results
Objective: To show the protective value and to measure cost effectiveness of higher Ig dosing on progression of lung disease in PAD.
The primary aim is to examine whether early addition of IVIg to standard treatment with prednisone in patients with newly diagnosed myositis leads to superior clinical outcome after 12 weeks. Our secondary aims are to examine the effect the…
The main aim of the proposed study is to 1) assess the habitual consumption of raw cow*s milk among a large population of adult dairy farmers; 2) assess the association between raw cow*s milk consumption and inflammation-related, auto-immune and…
The aim of this study is to compare the effectiveness of TAC with MMF as a second line treatment for AIH. Proportion of patients with CR after 12 months of treatment will be the primary outcome parameter to determine effectivity.
The main purpose of this study is to investigate the effect of nipocalimab on how quickly and to what extent etanercept or hydroxychloroquine is absorbed, distributed, metabolized and eliminated from the body. The study consists of 2 parts, Part 1…
In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…
To characterize the single-dose pharmacokinetic (PK) of RPV after SC administration of RPV LA suspensions with different doses and/or different particle size (PS) to support further dose and formulation selection, in healthy adult participants.To…
This study investigates the safety and efficacy of the new drug anifrolumab in patients with Lupus Nephritis. The effect of anifrolumab is compared with the effect of a placebo. Anifrolumab and placebo ("the study drug") are added to the…
The aim of this study is to investigate the efficacy of subcutaneous IFX in the treatment of moderate to severe Crohn*s disease with and without concomitant immunosuppression, as measured by the proportion of patients in corticosteroid-free clinical…
1. Define in detail how autoantibodies and changes in the B cell compartment correlate with different stages of clinical microvascular damage in SSc.2. Determine which soluble factors, including autoantibodies, in SSc-blood of clinically well-…
To confirm an age-adjusted optimum dose of efgartigimod IV and provide (model-predicted) evidence for a treatment response.
This is an exploratory study with two objectives:1. To investigate whether modification of allergenic milk and peanut proteins or peptides thereof with glycans can support oral tolerance induction by altering the antigen-specific T cell response…
We will assess the safety of adalimumab-800CW through the evaluation of both vital signs after tracer administration and possible (severe) adverse events (SAE/AE*s). Importantly, we will determine the feasibility of molecular fluorescence imaging…
To assess the effect of adding a tapering decision aid on a dynamic flare prediction model to disease-activity-guided dose optimisation (DGDO) on the incidence of flares and medication use.
We aim to describe the clinical characteristics and immune response in children seeking care for post-COVID complaints. Moreover, in a subset of children we evaluate the effect of the reinfection on clinical and inflammatory outcomes in children…
We aim to demonstrate the safety and feasibility of intranodal TolDCB29 administration. Our secondary objectives are the characterization of B29-peptide specific immune reactivity in response to TolDCB29 treatment and the evaluation of the effect of…
To assess clinical efficacy and safety of Leflunomide/Hydroxychloroquine in pSS patients in a phase IIb placebo-controlled randomized clinical trial at 24 weeks, followed by a single-arm crossover and an open extension (total duration of 48 weeks)…
The main objective of study 20190530 is to estimate the efficacy of Apremilast compared to placebo in the treatment of oral ulcers in pediatric subjects from 2 to < 18 years of age with oral ulcers associated with BD through week 12. See…
Gain a better fundamental understanding of the functioning of the human immune system.Our research focuses on the mechanisms involved in 2 aspects: 1. The induction of Tregs (and inhibition of Th2 cell polarization) by exposing DCs to certain…
Primary objective:To evaluate the efficacy of each active treatment combination (hydroxychloroquine + leflunomide and hydroxychloroquine + mycophenolate mofetil) based on proportion of responder patients according to preliminary STAR at week 24.…