90 results
The primary objective of this study is to investigate if shear-wave elastography and contrast-enhanced ultrasonography can identify those patients most suitable fir an intervention (surgery or endoscopic balloon dilation) and those patients that…
To compare the immunobiology of healthy volunteers to (advanced) cancer patients to age-matched controls with no history of cancer and no potentially interfering medication.
To assess the presence of absence of ILCs in preclinical (early) pSS biopsies as well as to assess their potential interaction with epithelial cells.
We hypothesize that telemonitoring through SpA-Net, in combination with patient-initiated care, will lead to less outpatient visits, without compromising quality of care and health outcomes. Furthermore, we expect that telemonitoring through SpA-Net…
Allergen immunotherapy (AIT) is currently performed with aluminum hydroxide-adsorbed allergen extracts. This approach is effective, but requires a long burdensome treatment protocol with a relatively high frequency of allergic side-effects. There is…
1) Establish a comprehensive clinical and antibody profile of autoimmune synaptic encephalitis in dementia syndromes. 2) To assess outcome and provide diagnostic guidelines who to test and in whom testing will be unnecessary, and elucidate…
The primary objective is to evaluate whether a switching strategy using adalimumab concentration (TDM) is superior to usual care in rheumatoid arthritis patients failing adalimumab treatment with regard to response rates. The secondary objectives…
The objectives of this study are to:• Assess safety and tolerability of imlifidase in combination with standard IVIg treatment in GBS subjects• Evaluate pharmacokinetics of imlifidase• Evaluate pharmacodynamic profile of imlifidase• Evaluate…
The purpose of this trial is to- determine the dose-response of iscalimab in a population of patients with moderate-to-severe Sjögren*s Syndrome (SjS), defined by ESSDAI >=5and ESSPRI >=5 (Cohort 1)- evaluate the preliminary efficacy…
To initiate a Dutch cohort with standardized follow-up measures and investigating blood, liquor, urine samples and nailfold videocapillaroscopy findings for prognostic factors during disease quiescence and at times of disease flare. This will…
Primary Objective:- To evaluate the efficacy of efgartigimod compared to placebo in achieving a sustained platelet count response in patients with chronic primary immune thrombocytopenia (ITP), with a sustained platelet count response defined as…
The purpose of this study is to investigate how safe the new compound GDC-8264 is and how well it is tolerated when it is administered to healthy volunteers. GDC-8264 has not been administered to humans before. It has been previously tested in the…
Primary objective: to evaluate the disease activity after dose reduction, aiming adalimumab concentration of 2 mg/L or 5 mg/L, in rheumatoid arthritis patients responding to adalimumab.Secondary objectives: to evaluate whether reducing adalimumab…
Primary: The main objectives of the study are to demonstrate feasibility and safety of gene corrected autologous CD34+-selected hematopoietic stem cell therapy using a lentiviral SIN vector encoding codon-optimized human RAG1 cDNA in patients with…
Primary objective1. The primary aim of the study is to answer the question whether specification of a positive direct antiglobulin test and/or red blood cell autoantibody specification is correlated with the clinical course in patients with AIHA. We…
We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.
The primary objectives of this study are to evaluate advanced MRI techniques (IVIM, T2*-mapping, motility) and advanced ultrasound techniques (CEUS, SWE and SICUS) to: 1. Identify advanced imaging techniques that correlate with stricture composition…
The main objective of this study is to describe the sequestration pattern of platelets in healthy adult volunteers. The secondary objective is to make a comparison between the sequestration patterns in healthy volunteers, and the patterns in ITP…
The main objective is to evaluate whether adalimumab dose reduction using adalimumab serum measurements (TDM strategy) will minimize medical costs, compared to disease activity guided dose reduction in rheumatoid arthritis (RA) patients.
To isolate and validate TCRs that exclusively recognize liver antigens presented by specific (*recipient*) HLA-molecules (LSARH) on the surface of tumor cells.