75 results
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…
The objective of the study is to determine the effect of BCG revaccination and high dose BCG vaccination on the induction and course of innate immune memory.
Primary: To identify potential diagnostic cytokine profiles for an allergic reaction towards a dental device in patients with symptoms of oral metal allergy. Which might lead to a better understanding of allergic based systemic reaction of oral…
1. To examine whether the PI3K-AKT pathway is overly activated in children with Down syndrome compared to healthy age-matched controls. 2. To determine the rate of exhaustion and the apoptosis of lymphocytes in children with DS. 3. To determine the…
1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…
The purpose of this study is to investigate how quickly and to what extent evobrutinib is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Part of the evobrutinib will be labelled with…
Primary objectives* To evaluate the safety and tolerability of multiple SYNT001 loading and maintenance doses in healthy subjects.* To determine the multiple dose pharmacokinetics (PK) of SYNT001 in healthy subjects.Secondary objectives* To evaluate…
This study's objective is to assess the bioavailability of phosphorus after oral intake of a new hypoallergenic infant formula compared to the bioavailability of phosphorus after oral intake of another hypoallergenic infant formula.
Aim 1: Confirm the hypothesis that the IgG4 qPCR test score correlates with disease activity in vasculitis as observed in the pilot study. Aim 2: Study IgG4-expressing B-cells from blood of vasculitis patients to understand their role in the…
Primary objective: To investigate whether AS patients have increased signs of microvascular abnormalities of the retina, compared with healthy controls.Secondary objectives: to investigate:1. the peripheral microvascular function in AS patients,…
Primary Objective: To assess dietary intake of macro- and micronutrients, body composition and serum levels of nutrients in patients with primary antibody deficiency and bronchiectasis. Secondary Objective(s): - To evaluate the correlation between…
To study PsO patients in the outpatient dermatology clinic in order to 1) to compare the sensitivity and specificity of the easy to use questionnaire: the Psoriasis Epidemiology Screening Tool (PEST) and ultrasonography in identifying PsO patients…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…
Development of improved peanut serum-based allergy diagnostics by preventing false-positive outcomes induced by specific IgE of sensitized but tolerant subjects. By means of our study results, improved allergens (i-allergens) for the diagnostic may…
To determine the value of quantitative whole body PET with [18F]PEG-Folate to predict development of clinical arthritis within one year follow-up in arthralgia patients with a positive autoantibody ACPA test.
The objective of this study is to evaluate the efficacy and safety of risankizumab compared with secukinumab for the treatment of adult subjects with moderate to severe plaque psoriasis who are candidates for systemic therapy.
Primary Objective: To compare the composition and functionality of neonatal microbiome arising from mothers receiving antibiotic prophylaxis before skin incision with the microbiome of neonates born when antibiotics are given after umbilical cord…
To gain a better understanding of NET formation by human neutrophils and the molecular mechanisms underlying this process.We would like to gain insight in:* The differences in NET formation upon the exposure of neutrophils to different stimuli.* The…
To deliver proof of concept that antifungal prophylaxis with posaconazole in addition to standard of care (SOC) can reduce the incidence of IAA in ICU patients with severe influenza, in comparison with SOC alone.To assess differences in cytokine…
Primary Objective: Evaluate the relationship between the amount of pollen collected in the environment of the hay fever sufferers using a handheld sniffer and the symptoms of these subjects.