931 results
We hypothesize that telemonitoring through SpA-Net, in combination with patient-initiated care, will lead to less outpatient visits, without compromising quality of care and health outcomes. Furthermore, we expect that telemonitoring through SpA-Net…
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
The main hypothesis is that specific mechanisms of action and level of immunosuppressive medication is the most important determinant of SARS-CoV-2 immunity after vaccination or infection in ISP patients.
Primary ObjectiveTo define normal values for synovial thickness in the healthy pediatric knee and wrist on MRI after intravenous gadolinium contrast administration. Secondary ObjectiveTo evaluate possible age-dependent variations in normal values…
The purpose of this study is to determine how diagnostic delay of CD affects the burden of CD to patients and society in terms of healthcare and mental healthcare utilisation and socioeconomic costs.
Primary Objectives: 1.1: To evaluate the feasibility of determining sensory thresholds in patients with JIA using QST.1.2: To examine which sensory modalities are particularly affected in JIA patients compared to healthy controls in order to define…
Determine whether the prevalence of allergic sensitilization, defined as at least one allergen specific IgE with a concentration of >= 0,35 kU/l, is lower in people with than without DS. Analyse whether this prevalene is depending on age, how…
This study aims to determine whether the ILC populations differ in the lungs of different phenotypes of asthmatic patients and healthy subjects and how these cells are regulated by bronchial epithelial cells. Furthermore we want to study how this is…
The aim of the project is to test BS6.890C in the prophylactic transplant model of psoriasis.
The main objective of this study is to assess the effects of rituximab (RTX) as a rescue therapy for therapy resistant progressive IMID- IP patients. Specifically there is an objective assessment of (1) pulmonary function tests (PFTs) and (2)…
Primary objective:To demonstrate bioequivalence of GP2015 applied by an autoinjector (delta-GP2015_50) and a pre-filled syringe (PFS) as single subcutaneous injection of 50 mg to healthy adult male subjectsSecondary objectives- To study and compare…
The purpose of the study is to investigate to what extent ALX-0061 is tolerated. It will also be investigated how quickly and to what extent ALX-0061 is absorbed and eliminated from the body (this is called pharmacokinetics), and how much of the…
The main objective of the study is to investigate whether the strong clinical effects of natalizumab in RRMS can be explained by enhanced functional adaptation mechanisms of the brain and whether enhanced functional reorganisation is sustained over…
The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.
- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…
The main objective of this study is to assess the effects of rituximab (RTX) as a rescue therapy for therapy resistant progressive IMID- IP patients. Specifically there is an objective assessment of (1) pulmonary function tests (PFTs) and (2)…
The objective of this study is to explore the efficacy and safety of gevokizumab in patients with Schnitzler syndrome.
To investigate the effect of anti-IL6 therapy with tocilizumab on subclinical arterial inflammation (endothelial dysfunction) and stiffness in patients with treatment resistant rheumatoid arthritis at baseline and after 6 months treatment
Primary Objective: To determine for a series of drugs frequently used perioperatively the maximal non irritative concentration in intracutaneous skin testing in healthy volunteers. Secondary Objective(s): To compare the percentage/number of positive…