56 results
Objective: To compare histology, gene expression profile (using transcriptome analysis and quantitative Polymerase Chain Reaction (qPCR) validation) and the microbiome of vesicular endogenous hand eczema between and within patients and to skin of…
The overall aim of the study is to improve our understanding of the role of T cells and ILCs in cutaneous GvHD, to lay the foundation for the development of better therapies to treat cutaneous GvHD.1. T cells in GvHDThe dominant cell population in…
The aim is to investigate the differences in pathogenesis of nonbullous and bullous pemphigoid by comparing gene expression, and the presence of activated and apoptotic eosinophils and IL-31 expression in skin, blood and blister fluid of both…
o To test the linearity of the LSCI device (Perimed AB, Järfälla, Sweden) and LDI device (Moor Instruments, Devon, UK) in a wide range of blood flux valueso To compare arbitrary units of two different kinds of laser-based devices and to create a…
To compare histopathology and immunofluorescence expression of keratins, epidermal barrier proteins and adhesion molecules in hyperkeratotic hand eczema (lesional skin) and non lesional skin of the palms in patients, compared to healthy individuals…
The purpose of this study is to investigate how safe the new compound ZPL389 is and how well it is tolerated when it is administered to healthy volunteers. ZPL389 has been administered to humans before. It has also been previously tested in the…
To compare the effectiveness of MTX monotherapy with MTX and LEF combination therapy in cDMARD-naïve psoriatic arthritis patients.
5.1 Study hypothesisThe primary study hypothesis states that oral treatment with itraconazole will reduce the epistaxis severity score (ESS) due to the anti-angiogenic effects of itraconazole.5.2 Research question and primary outcomeWhat is the…
Primary: To identify potential diagnostic cytokine profiles for an allergic reaction towards a dental device in patients with symptoms of oral metal allergy. Which might lead to a better understanding of allergic based systemic reaction of oral…
The aim of the project is to study the effect of JW 1-3 test compounds on typical skin features of psoriasis. This information can establish the most effective compound, right formulation and dose for further clinical research.
In this project we will establish primary keratinocyte cell lines of patient skin biopsies from selected skin diseases, to generate 3D skin constructs. In addition, patient DNA will be genotyped for genetic risk factors (psoriasis and AD) or…
Studying whether the effectiveness of Medical Moisture Retention Cream (Alhydran®) is greater than that of Cetomacrogolcrème FNA on duration healing of matig ernstig venous eczema, as well as reduction of the complaints associated with venous eczema
To determine the prevalence of enthesitis, both clinical and on US, in patients with HS.
To assess the immunomodulatory effects of erythromycin and clindamycin in healthy volunteers.
Primary ObjectiveThe primary objective of this study is to evaluate the initial efficacy, safety, and tolerability of guselkumab in adult participants with moderate to severe hidradenitis suppurativa (HS).Secondary ObjectivesThe secondary objectives…
Primary objective:To demonstrate that tralokinumab in combination with TCS is superior to placebo in combination with TCS in treating moderate-to-severe AD.Secondary objectives:To evaluate the efficacy of tralokinumab in combination with TCS on…
To explore the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of LOU064 over a treatment period of 4 weeks in a cohort of subjects with atopic dermatitis.
1. To estimate the incidence and severity of fungal infections during anti-Th17 mAb therapy2. To characterize the determinants (clinical, immunological, mycobiome/microbiomeand genetical) for developing fungal infections during anti-Th17mAb therapy…
The aim of the project is to study the effect of ALPN test compounds on typical features of the chronic disease psoriasis. This information can establish the most effective compound with the right formulation and dose for further research (e.g. in…
The primary goal is to evaluate the presence and type of skin disorders in patients with a PID. Secondary objectives are to determine the presence of S. aureus on the lesional skin and/or nose in patients with a PID and to evaluate the presence of…