617 results
To assure the continued safety and effectiveness of the Tryton Side Branch Stent* with main branch approved DES in the treatment of de novo native coronary artery bifurcation lesions with side branch diameter ranging from >=2.5 mm to <…
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
To determine the add-on value of bi-atrial pacing in combination with standardised Sotalol treatment for the prevention of postoperative atrial fibrillation (POAF).
The primary aim of the ISCHEMIA trial is to determine whether an invasive strategy of routine early catheterization followed by optimal revascularization, in addition to OMT, will reduce the primary composite endpoint of cardiovascular death or…
Primary objective:Investigate the efficacy and safety of Vernakalant in the acute conversion of AF, as compared to Amiodarone and rate control alone, in critically ill patients admitted to the medical and non-cardiac surgical ICU.Secondary objective…
To evaluate different cryoenergy application times using absence of DC as a surrogate for permanent PV isolation to establish optimal duration for formation of contiguous lesions and prevention of right PNP and esophageal thermal lesions during…
The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…
To study whether CMR analysisdifferences in aortic stiffness and myocardial lipid accumulation between SCT recipients and healthy, age-matched controls
The aim of this study is to answer the question: *Will the addition of the lipoprotein profile to the conventional diagnostics for dyslipidemia in T2D patients, lead to a better risk classification of CVD development?*. The improved risk…
To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.
To identify genetic modifiers by means of whole-exome (or targeted-genome) sequencing of members of this founder population. Secondarily, to establish a comprehensive genotype-phenotype correlation, focussing on clinical and cellular…
1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…
To predict atherosclerotic plaque progression, and thus cardiovascular risk, by combining plaque quantification on CCTA with semi-automated software combined with biochemical characteristics, as defined by measuring biomarkers involved in…
Primary:To understand the relationship between novel risk markers (based on the following) and clinical outcome. Secondary:Developing a score from the predictive model that can be used to assess risk given a patient*s combination of risk factors.
1. to gain mechanistic insight into the impact of ConHD on growth, renewal and homeostasis of the heart, especially the RV2. to improve identification of patients at risk for attrition of heart function in ConHD3. to establish the context to develop…
The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…
This randomized controlled trial is designed to prospectively assess the safety and efficacy of a CE-marked paclitaxel-eluting balloon only strategy versus third generation DES in the setting of a STEMI. This inferiority design serves to demonstrate…
The primary objective of this study is to assess the CV risk profile of Hindustanis without known diabetes mellitus (DM), hypertension, dyslipidemia or CV disease and evaluate the 10-year CV risk according to the Framingham risk score. Secondary…
Employing PPCM patient-derived iPSCs, we aim to test our hypothesis that cardiomyocytes from PPCM patients exhibit (epi)genetically determined differences in protein expression profiles and functional behavior in comparison to those from healthy…
The aim of this study is to determine if adding ablation restricted to specific areas of the left atrium to PVAI is superior to the standard care PVAI alone.