124 results
In this study we would like to investigate the clinical effectiveness of a smart technology intervention (The Heart Failure Box) in heart failure patients from the department of Cardiology at Leiden University Medical Center.
To evaluate the safety, tolerability and efficacy of IZD334 to reduce CRP in cardiovascular high-risk patients.
To develop a prediction model for ICD-therapy in a study population of ICD and CRT-D patients using a multimodal dataset containing clinical and historical data from electronic health-records, remote monitoring-data, accelerometer-derived data and…
The objection of the study is to assess the safety, tolerability, and effect on microvascular obstruction of study drug in subjects undergoing Percutaneous Coronary Intervention.NL specific sub-study:The aim of this substudy is to investigate…
Primary Objective:The aim of the study is to assess the effect of an additional home-based training module during CR and post-CR on physical activity levels among coronary artery disease (CAD) patients.Secondary Objective:The secondary aim of the…
Co-primary Objectives:1. To assess the interobserver agreement between the pre-hospital HEART-score calculated by ambulance personnel and the in-hospital HEART-score calculated by emergency physicians.2. To evaluate the diagnostic performance of a…
Our main objective is to identify disease modifiers in PLN r14del cardiomyopathy by studying patients are different ends of the PLN r14del cardiomyopathy disease spectrum with respect to differences in the circulating proteome and metabolome and in…
A real world registry to compare dual therapy with Dabigatran/Clopidogrel to Usual care (Triple Therapy) with Dabigatran/Clopidogrel/Aspirin in patients with an indication for NOAC undergoing PCI in the setting of ACS. Hypothesis: Dual therapy with…
Our objective is to study if reduced anticoagulation targets diminish bleeding complications without an increase in thromboembolic complications or a negative impact on outcome.
The objective of this study is to evaluate the feasibility and safety of the Millipede Transcatheter Annuloplasty Ring System in patients with functional mitral regurgitation.
To investigate the effects of Dobutamine on RV contractility and oxygen consumption in patients with pulmonary arterial hypertension (PAH).
To determine the ratio of parent drug to metabolites in the circulation.Profiling of [14C]-etripamil metabolites in blood, urine and feces.To determine the mass balance of drug-related materials following intranasal administration.To determine the…
To assess T cell activation in patients with extremely high Lp(a) levels versus controls with low Lp(a)
This study has a strong explorative and qualitative approach and set-up. Please note that the goal of the study is to further identify possible areas for innovation for professionals, patients and their partners. The aim for this study is NOT to…
To assess the efficacy of treatment with sulodexide for chronic heart failure.
Primary ObjectiveThe goal of the study is to evaluate hemostasis (i.e. coagulation activation, platelet reactivity, overall thrombus formation and fibrinolysis) following LAAO in a longitudinal design for hypothesis-generating purposes. Several…
To assess risk factors for cardiomyopathy and heart failure among lymphoma (HL and aggressive B-cell NHL) survivors, focusing on the independent and joint effects of doses of anthracycline-containing chemotherapy (doxorubicin) and rituximab as well…
In this explorative-study, we aim to investigate the relation between cDPP3 release kinetics and clinical outcome parameters in OHCA patients after ICU admission. This could lead to the identification of a new predictive marker, a potential…
The objective of this study is to demonstrate that use of the Sentinel® Cerebral Protection System significantly reduces the risk of periproceduralstroke (*72 hours) after transcatheter aortic valve replacement (TAVR).
The primary aim of this explorative study is to compare exercise-induced cardiac troponin elevations between athletes with different levels of coronary atherosclerosis. The secondary aim is to compare exercise responses to other cardiac biomarkers…