120 results
The primary aim is to assess myocardial development and function of the left ventricle in fetuses with the suspicion of aortic coarctation on fetal echocardiography. The secondary aim is to study left ventricular blood flow movement with vector…
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
HFpEF patients have impaired peripheral microvascular function compared to controls without HFpEF, with correction for important confounders of microvascular function.
Identify, if any, both structural and functional changes related to LVOT desobstruction in asymptomatic with exertional LVOT pressure gradients >50 mmHg (or >30 mmHg in rest)
Primary objective:Determine the short- and long-term safety and tolerability of single and multiple doses of NI006 in subjects with ATTR-CM by evaluating adverse events (AE) and serious adverse events (SAE) and changes in laboratory parameters (…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
To determine the efficacy of ALNTTRSC02 in patients with hATTR amyloidosis by evaluating the effect on neurologic impairment. To determine the efficacy of ALN-TTRSC02 on quality of life, gait speed, neurologic impairment, nutritional status, and…
Key PrimaryPart A• To determine the efficacy of acoramidis (AG10) in the treatment of subjects with symptomatic transthyretin amyloid cardiomyopathy (ATTR-CM) by evaluating the difference between the acoramidis and placebo groups in the change from…
Is targeting an ACT > 400 seconds equivalent compared to an ACT > 480 seconds with respect to PRBC transfusion rates during hospitalization in patients undergoing cardiac surgery with cardiopulmonary bypass?
To compare the relative efficacy of sonothrombolysis in the acute management of STEMI following primary percutaneous coronary intervention [PCI] in patients with persistent ST elevation compared with standard of care.
Primary objective Primary objective is to create a prediction model based on early clinical screening of motor, cognitive, and emotional disturbances to predict restrictions in participation at one year after cardiac arrest in patients that have…
The purpose of this study is to investigate how safe the new compound BAY 2413555 is and how well it is tolerated when it is administered as a single oral dose to healthy volunteers. BAY 2413555 has not been administered to humans before. It has…
The aim of this trial is therefore to determine the effects on mortality and rehospitalization rate of a targeted correction of plasma sodium concentration in addition to current standard care in hospitalized hyponatremic patients.
Primary Objective:- to evaluate whether the oral FXIa inhibitor BAY 2433334 leads to a lower incidence of CV death, MI, stroke and stent thrombosis following an acute myocardial infarction when compared to a placebo- to evaluate whether the…
Evaluate and quantify whether lesion formation can be visualized using MRI in subjects undergoing a catheter ablation for paroxysmal atrial fibrillation.
To date, no dedicated prospective, randomized, blinded trials have been performed to assess the benefit of CRT in patients with NICD. It is difficult to hypothesize whether CRT implantation may be beneficial in patients with NICD. The objective of…
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal, neurocognitive and cardiovascular health (dependent variables) of professional…
The goals of the Urimon study is to test the hypothesis that microRNA expression profiles in periodic urine- and blood samples from individuals can be used for the sensitive detection of the onset of disease.
To investigate if a QFR-based diagnostic strategy yields non-inferior 12-month clinical outcome compared to a standard pressure-wire guided strategy in evaluation of patients with stable angina pectoris and intermediate coronary stenosis.
Main objectives are:1. To explore differences in cerebral perfusion and flow pulsatility between CoA patients and controls.2. To quantify ischemic white matter lesions and cerebral microbleeds in CoA patients with comparison to controls.Secondary…