160 results
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
The primary objective is to establish the non-inferiority of the Synergy stent relative to the Xience stent for prevention of MACE. The effect measure is the difference in the rate of MACE in patients randomized to treatment with the Synergy ( index…
The aim of the study is to test the hypothesis that intermittent intravenous paracetamol administration in children after cardiac surgery will result in a reduction of at least 30% of the cumulative morphine requirement.
Primary Objective: Identification of genetic variants causative of CHD. Expression of candidate genes in a zebrafish model. Overall goal is to gain insight in cardiac development by expanding our knowledge of genetic components in de novo and…
Primary: To identify whether PCR-proven rhinovirus is a risk factor for prolonged PICU admission in children undergoing cardiac surgery. Secondary: to develop a preoperative algorithm to identify children with increased risk for prolonged PICU…
To demonstrate that a single intracoronary infusion of autologous bone marrow-derived mononuclear cells in addition to state of the art treatment is safe and reduces allcause mortality in patients with reduced left ventricular ejection fraction (…
To assess whether atrial flow patterns during sinus rhythm in patients with atrial fibrillation differ from healthy controls with sinus rhythm.
The primary aim of the present registry is to assess a risk profile including biomarkers and genetics, associated with failure of the cryoballoon AF ablation, so we can predict failure of the cryoballoon AF ablation. Failure will be assessed within…
The objective of the study is to evaluate the effect of physical exercise on exercise capacity, quality of life and serum NT-proBNP levels in adult patients with congenital heart disease.
The current randomized controlled trial should investigatewhether- 2 sequential intracoronary BM-MNC applications are associated with a lower mortality than oneintracoronary BM-MNC application- 2 intracoronary treatments with BM-MNC are associated…
To determine a risk profile based on clinical correlates, circulating biomarkers, and genetic background associated with failure of the hybrid AF ablation procedure.
The main objective of this study is to biochemically and histologically validate two novel MRI techniques to characterize myocardial properties that are expected to be useful for the diagnosis of various forms of cardiomyopathy. A second objective…
The objective of this study is to establish the safety and effectiveness of a dual epicardial and endocardial ablation procedure for patients presentingwith Persistent Atrial Fibrillation or Longstanding Persistent Atrial Fibrillation utilizing the…
Primary:To demonstrate the safety of enalapril Orodispersible Minitablets (ODMTs).Secondary:1. To describe the acceptability and palatability of enalapril ODMTs..2. To collect additional information about pharmacokinetics and pharmacodynamics of…
Assessment of coronary artery disease (plaque and stenosis) by low-dose coronary Computed Tomography (CCT), with both non-contrast CT for coronary artery calcium scoring (CACS) and contrast-enhanced CT coronary angiography (CCTA) and additionally a…
To compare acute cardiotoxicity, measured by Troponin difference pre- and post-implantation, induced by implantation and defibrillation testing of transvenous and subcutaneous ICDs.
The aim of the study is to compare the outcome of the bioresorbable polymer coated stent (ORSIRO) and a new generation permanent polymer coated stent (RESOLUTE ONYX) in an allcomers patient population and non-inferiority setting.
Primary Efficacy Objectives:The primary efficacy objective of this trial is to evaluate the placebo-adjusted change in HbA1c from baseline after 24 weeks of exposure to bexagliflozin in type 2 diabetic subjects with increased risk of cardiovascular…
The primary objective of this study is to validate 31P-MRS as a non-invasive in vivo measure of mitochondrial function. Secondary objectives are to determine whether there is mitochondrial dysfunction in the heart of type 2 diabetic patients and to…
The idea behind this study is to show that stem cell therapy is not just effective and safe but also an accessible, feasible and economically sound therapeutic option for patients with IHD and severe heart failureThe present aim is to perform at…