60 results
To evaluate the effect of KW-3902IV in addition to IV loop diuretic therapy on heart failure signs and symptoms, persistent renal dysfunction, morbidity and mortality, and safety in subjects hospitalized with acute heart failure syndrome, volume…
The study objective is to evaluate the safety and efficacy of the Ablation Frontiers Cardiac Ablation System in the treatment of permanent atrial fibrillation.
The primary objective of this study is to evaluate safety and efficacy of the BIOTRONIK PRO-Kinetic coronary CoCr-stent in patients with single de novo lesions of native coronary arteries.
To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.
In this study we will study the incidence of QTc-interval prolongation when combinations of 2 or more QTc-prolonging drugs are prescribed. Also we will investigate if QTc-prolongation is more frequent in patients with higher drug plasma…
The primary hypothesis of our study is that volumetric monitoring will allow for more effective and targeted fluid administration compared to pressure (PAC) monitoring, thereby allowing the attending physician to better optimize fluid infusion…
In this trial, current usual care concerning cardiovascular education is described. Second aim is to study what is understood of this education by the patient. Last aim is to study what effect training of GP's on this subject will have on the…
The primary objective of this study is to establish the effects of a single bolus EPO administered just before a primary PCI for a first acute myocardial infarction, on left ventricular ejection fraction after 6 weeks, measured with planar…
The primary objective of this study is to demonstrate that the efficacy of cangrelor (combined with usual care) is superior to that of usual care, in subjects requiring percutaneous coronary intervention (PCI) as measured by a composite of all-cause…
The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.
The purpose of this study is to determine whether the application of ventricular pacing during PCI for AMI can protect the human heart from damage as a result of ischemia/reperfusion injury
To assess the effectiveness of pacing therapy for preventing syncope recurrence inpatients with a high probability of neurally-mediated syncope different from carotid sinus syndrome.
Does melatonin by improving sleep parameters improve quality of life of hemodialysis patients?
Secondary HPT is common in people with CKD. Patients with secondary HPT often have high PTH levels and may develop large parathyroid glands in the neck. Patients with secondary HPT may have bone disease (osteodystrophy). This bone disease may cause…
There are two phases in this trial with 2 objectives:In phase I of the trial it will be assessed which dose of rivaroxaban is the most safe and effective (most optimal benefit:risk profile). In phase II this dose will be further investigated to…
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
To find the predictors of ventricular arrhythmias in patients receiving an ICD
Primary:Comparing EPO induced proliferation, G2/G0 ratio, and apoptosis of UT7-EPO cells between anemic and non-anemic CHF patients. Secondary:1. Comparing the levels of several circulating inhibitory factors (TNF-alpha, TGF-Beta, Ac-SDKP, INF-gamma…
Monitoring the haemodynamic status during lung recruitment.
The primary objective of this study is to determine the feasibility and safety of the Genous Bio-engineered R stent in the treatment of patients presenting with acute myocardial infarction with ST segment elevation within 12 hours of symptoms onset…