28 results
1. To establish reference intervals for thyroid hormones in plasma at the time of the neonatal screening (day 3-7 of life).2. To establish reference intervals for thyroid hormones in plasma around the 14th day of life.3. To compare the…
To assess the prevalence of hypothyroidism and hyperthyroidism in the entire cohort of childhood cancer survivors and the therapy related risk factors. Specifically:Part I: 1. To systematically review existing studies on the association between…
1. To assess the prevalence of severe male subfertility in adult male survivors of childhood cancer in relation to type and intensity of treatment and age at time of treatment. 2. To assess the diagnostic value of inhibin B and AMH for the…
To evaluate whether a dietary advice of green vegetables, beef and whole dairy products during six months including standard supportive care can decrease the TSH-level compared to standard supportive care alone in children aged 1-12 years with…
To assess the diagnostic accuracy of total and free IGF-1 concentrations by comparing it to the gold standard for detection of growth hormone deficiency in adults, i.e. the insulin tolerance test, in subgroups of patients at risk for growth hormone…
Primary Objective: To compare the effects of hypothyroidism and hyperthyroidism on cardiac left ventricular function, as assessed by CMR, in subjects with differentiated thyroid cancer during their early treatment.Secondary Objective(s): To compare…
Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…
The aim of this study is to investigate if the NETest is useful in the follow up program after curative resection in patients with pNET. Therefore the diagnostic accuracy of the NETest in resected patients with pNET will be analysed. The study is…
To determine the sensitivity and specificity of salivary metanephrines and in patients with PCC/sPGL.
Objectives:Primary Objective: • To assess the safety and tolerability of single and multiple ascending doses of BIM23B065 when given as a subcutaneous (s.c.) bolus injection in young healthy male subjects.Secondary objectives:• To determine the…
Primary objective:a. How often do inhalation or nasal corticosteroids lead to suppression of the HPA- axis in HIV-treated patients? Secondary objectives:b. Are other variables associated with the HPA-axis suppression? c. Are cortisol measurements in…
Primary Objective- Compare the safety and efficacy of subcutaneous somavaratan and daily rhGH during 12 months of treatment.Secondary Objective-Evaluate and compare changes in pharmacodynamic responses (IGF-I, IGF binding protein-3 (IGFBP-3), growth…
The primary aim for this study therefore is:1. To study the effects of an 8-week exercise training on RNA expression profiles in adipose tissue and skeletal muscle in obese individualsSecondarily we also aim:2. To relate changes in RNA expression…
To compare Bone Material Strength of the tibia at the side of a fracture or arhtrodesis with that of the opposite tibia in patients who had been immobilized for at least 6 weeks after a recently sustained fracture of the ankle of calcaneus or after…
The primary objectives :Are children of mothers with sub-optimal thyroid function and/or sub-clinical hypothyroidism and/or hypothyroxinemia during early pregnancy at risk for developmental delay at the age of two and does this possible delay…
Objective: The primary objective of the study is to determine the effect of standard treatment with levothyroxine in TR*1 deficiency on:- Neutrophil and macrophage function- Erythropoiesis- Thyroid hormone target gene expression- Plasma metabolome
Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?
Primary objective:We hypothesize that genetic variability influences mitotane pharmacokinetics. Therefore our aim is to explore the inter-individual differences in genes coding for drug metabolizing enzymes in patients treated with mitotane and to…
The primary study objective is to assess the proportion of patients who remain within the IGF-I age adjusted normal limits with pasireotide LAR (60 mg) monotherapy, after 24 weeks of treatment.Secondary study objectives are assessment of the…
Determination of prognostic value of intraoperative growth hormone levels on postoperative curation for acromegaly in patients undergoing transsphenoidal resection of pituitary adenoma.