31 results
1. Normalization of the abnormal serum TH parameters and thereby improving the clinical condition of the AHDS patients2. Observation of changes in cognitive and motor function.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
To assess the impact of treatment with rhGH on circulating Klotho levels in paediatric patients with IGHD.
To study the extent of impaired urinary concentrating ability in hypothyroidism as well as the pathophysiological mechanisms involved before and after adequate treatment.
The effects of intravenous TRH administration on brown adipose tissue activity in healthy, lean men.
To investigate whether BAT tissue can be activated by intravenous administration of TRH. Secondary objectives are to determine whether intravenous TRH increases the degree of cardiovascular sympathetic stimulation and the response of skin…
1) To perform gene mutation analysis in family members of patients carrying a proven mutation in the candidate gene.2) To determine the clinical, biochemical and radiological characteristics of carriers of a mutation in the candidate gene.3) To…
The purpose of Part 1 of the study is to investigate how quickly and to what extent KHK7580 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). The compound to be administered will be…
Primary: characterize the long-term safety and tolerability of AMG 416 in the treatment of secondary hyperparathyroidism (SHPT) in subjects with chronic kidney disease (CKD) on hemodialysis.Secondary: to characterize intact parathyroid hormone (iPTH…
To determine whether the attenuated salivary cortisol response in children with asthma can be explained by the maintenance use of inhaled cortiocosteroids, the chronic inflammatory disease, or the attenuated exercise capacity.
The primary objective is to investigate the efficacy, safety and tolerability of RV 001 (a fully human anti-IGF-1R antibody) administered q3W for 6 months, in comparison to placebo, in the treatment of patients suffering from active TED.Secondary…
The purpose of this study, is to evaluate the efficacy and safety of pasireotide alone or in combination with cabergoline in patients with Cushing*s disease as measured by the proportion of patients achieving normal UFC at the end of the study…
To investigate the effect of androgeninsufficiency on sexual function in women with POI. Also, to map the sexual dysfunction in different domains and compare this data to medically healthy women with sexal problems and medically healthy women…
To find new genes causing congenital MPHD associated with the characteristic MRI abnormalities of ectopic posterior pituitary gland and absent/thin pituitary stalk.
A core part of the scientific efforts of ENS@T researchers bases on the establishment of a common registry and associated collection of biomaterials. Patients with adrenal tumours prospectively included in the ENS@T registry will be asked to provide…
To assess the changes in cardiac function and the microcirculatory function in different thyroid states. We aim to identify how thyroid state affects changes in micro and macro hemodynamics.
ObjectiveThe main goal of this investigation is to evaluate the thyroid hormone response in patients with TMNG and control subjects in response to various pharmacological and physiological stimuli, administered according to the dynamic exposure test…
Purpose:The main focus of our study is the development, implementation and evaluation of a self-management intervention for patients treated for pituitary adenomas and patients with endocrine diseases in general.
1a. Compare fat endocrine function in obese fit versus obese unfit people under resting conditions and immediately after exercise.1b. Compare fat endocrine function in non-obese fit versus non-obese unfit people under resting conditions and…
To detect potential genomic denominators between tumorgenesis factors in neuroblastoma and differentiated thyroid carcinoma.