40 results
Primary objective1.To determine the characteristics, frequency and severity of vascular, metabolic and hormonal side effects of angiogenesis inhibitors and EGFR inhibitors.Secondary objectives1.To investigate if steroid profile, indol profile,…
To evaluate the efficacy of Lanreotide Autogel 120 mg when used as primary medical treatment in untreated de novo acromegalic patients with macroadenoma
We will evaluate the acute effects of GH on, and its relation with, cognition in healthy subjects. The present proposal focuses on the following questions:1. Does an acute rise of plasma GH levels have a (beneficial) effect on cognitive performance…
The aim of this study is to investigate how often thymic hyperplasia is present in Graves' disease. Moreover we will investigate if thymic hyperplasia in Graves' disease is caused by stimulation of T cell development in the thymus.
To determine the additiotinal value of EUS and 11C-5-HTP PET scan for detection of pancreatic NET.
In this study we want to investigate long-term follow-up of patients with PA. The outcome will be analyzed based on whether a decision to treat was guided by CT/MRI or AVS or both.
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The effect of rLH for controlled ovarian hyperstimulation in order to achieve an increase of 10% in top quality embryos.
The objective of this observational study is the safe introduction of clinical applied IVM in The Netherlands. During this study, the number and quality of the oocytes and embryos will be studied as well as pregnancy development. Emphasis will be on…
ObjectiveTo assess the prevalence of PHD and chronic fatigue in Dutch TBI patients, and to study the relationships between the various aspects of chronic fatigue and PHD, with particular emphasis on the association between chronic fatigue, and…
to investigate whether showering shortly after Androgel application adversly affects plasma testosterone levels.
The aim of the present study is to assess the necessity of dietary restrictions before sampling for the biochemical diagnosis of pheochromocytoma. Therefore, the short-term influence of a catecholamine-rich diet on plasma free and total metanephrine…
To examine the effects of odors and / or visual stimuli of food in subjects after 56h of starvation on:-Endocrine parameters-Metabolic parameters-Anthropometric parameters-Autonomic nervous system parameters-Hypothalamic function
The aim of this study is to classify hyothalamic dysfunction in patients treated for pituitary tumors. The hypothalamic functions will be investigated in different studygroups, these groups each have a different risk on hypothalamic dysfunction.
To determine whether hypothalamic response to glucose ingestion in patients with anorexia nervosa differs from that in healthy subjects.
Does bilateral deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease influence plasma triglycerides and glucose metabolism?
To study the prevalence of hypopituitarism and osteoporosis in patients 5 tot 10 years after severe traumatic brain injury
1. Characterization of patients with persistent and recurrent primary hyperparathyroidism after at least one parathyroidectomy, with removal of at least one pathological parathyroid gland.2. Evaluation of pre-operative localization studies;…
The hypothesis is that women who have the Ser680Ser (SS) variant of the FSH receptor genotype, in comparison with women with the Ser680Asn (NS) or Asn680Asn (NN) variant, are less sensitive to FSH and because of that need higher dosages of FSH when…
To study whether higher estradiol levels in obese men are responisble for the lower testosterone levels also found in these men