561 results
In order to confirm and externally validate the novel panel of genes identified in our study (06/101/K) to be significantly predictive of recurrent implantation failure, we will recruit 50 additional subjects treated by IVF who have undergone at…
The purpose of this study is to look at the effect of changing from monthly (4 weekly) injections of your usual treatment (octreotide LAR) to less frequent treatment (once every 6 or 8 weeks) with lanreotide Autogel 120 mg injections. The study…
To find new genes causing congenital MPHD associated with the characteristic MRI abnormalities of ectopic posterior pituitary gland and absent/thin pituitary stalk.
Imaging disease activity in patients with Graves' orbitopathy using [18F]-FDG-PET/CT - a pilot study
To determine whether 18FGD-PET/CT imaging is able to show difference in [18F]-FDG uptake in orbital tissue between patients with active and inactive GO.
Our primary objectives are:- to estimate the prevalence of central adrenal insufficiency , defined as a plasma cortisol response <500 nmol/l in the low-dose ACTH test (see paragraph 8.3.5 of the protocol). - to describe immune dysfunction, i.…
The main objectives of this study are to investigate 1) in vivo dermal absorption of Ag ions from the Silverwear ® garments in healthy versus atopic skin, 2) effect of dermal exposure to Silverwear ® garments on release of inflammatory cytokines in…
The objective of the study is to determine whether it is necessary to take the blood pressure lowering medication (β-blocker, ACE-inhibitors or diuretics) of a patient into account prior to blood sampling for pheochromocytoma diagnostics. Therefore…
The aim of this study is to investigate whether a physiologically low hydrocortisone (HC) dose is better for cognition as compared to a high hydrocortisone dose. In addition, quality of life, metabolic profile and somatosensation will be described…
Aim of our study is to investigate the influence of HPT secondary to moderate-severe vitamin D deficiency and vitamin D replacement on the coagulation and fibrinolysis system
The study will be designed as a multicenter study to evaluate the impact of several parameters influencing the sensitivity and specificity of skin self tests.The parameters are:- Product applied: hair colouring formula mixed with developer (in use…
The primary objective of this study is to compare the therapeutical effect on atopic dermatitis of a standard used emollient (Unguentum leniens FNA) compared to a skin barrier repair cream (Dermalex Eczema), assessed by clinical and subjective…
The present proposal aims at detecting the pathogenesis of keloids in RTS by studying 50 RTS individuals from 3 countries (Netherlands, Norway, UK) with keloids clinically, and take 3 biopsies in 5 of them from normal skin, edge of normal skin-…
Our primary objective is to visualize the vascular involvement in the pathogenesis of psoriasis with the TOPCam. In particular we asked the following questions:(i) Can the TOPCam image the structure of vascular changes in the clinical lesions?(ii)…
Evaluation of the effect of single oral doses of lorazepam on plasma concentration of prolactin
Evaluating the efficacy and safety of sunitinib in patients with progressive, advanced/metastatic well-differentiated, unresectable pancreatic neuroendocrine tumors.
Primary Objective: To determine the differences in function and morphology of the distinct abdominal adipose tissue depots (e.g. SAT, PVAT, OAT and MAT; see figure 1) in patients undergoing elective open abdominal aortic surgery.Secondary…
1. To assess the effect of odanacatib 50 mg once weekly versus placebo on lumbar spine BMD over 24 months.2. To assess the safety and tolerability of odanacatib 50 mg once weekly compared to placebo.
This research aims to conduct blistering and reduce freguent dressing changes in patients undergoing total hip replacement or total knee replacement have undergone in the use of Aquacel Surgical dressing.This compares with the usual method of wound…
The aim of the current proposal is to investigate the effects of changes in lifestyle, food intake, physical activity and health related behavior during adolescence on development of asthma, allergy and other chronic diseases. Health outcomes that…
The purpose of the present randomized controlled pilot study is to assess the efficacy, safety and practical aspects of autologous epidermal cell suspension grafting using ReCell in segmental vitiligo and piebaldism patients. Results of this study…