57 results
The objectives of this open-label study are to evaluate the efficacy (GL-3 clearance), pharmacokinetics (PK), and safety parameters (including immunogenicity) for 2 alternative dose regimens of Fabrazyme (0.5 mg/kg every 2 weeks [q2w] and 1.0 mg/kg…
Primary objective:What is the effect of a 12 weeks physical exercise program on the exercise induced inflammatory response in patients with cystic fibrosis?Secundary objectives:- What are the differences in pre-training basal immune values of…
Riskreduction of developing breast carcinoma by means of better surgical techniques (removing all normal breast tissue).
The study aims at examining the effect of an individual tailored lifestyle intervention to reduce the cardiovascular disease risk in people with FH.Secundary, the study aims at promoting a healthy lifestyle (no smoking, proper nutritional pattern,…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
to evaluate the effects of GH versus withdrawal of GH, after final height is reached, on weight, body composition, psychosocial functioning, carbohydrate metabolism, circulating lipids, and respiratory function during transition period until the age…
We want to investigate if it is possible to set up the entire process of home mechanical ventilation outside the hospital. This means practically that the patients will not be admitted to the hospital. The goal of this study is to answer the…
Primary objective: -to determine if there is a significant difference in the incidence of oxygen dependency at day 28 and/or death within the first 28 days of life between newborns with congenital diaphragmatic hernia treated with high frequency…
The aim of the present experiment is to test whether the normally right-lateralised response to emotional prosody is reduced in KS.
The aim of this study is to invite a new cohort of CADASIL patients for a 7 Tesla MRI scan. By doing this, we aim to get more insight into the pattern and development of cortical atrophy and vessel wall thickening in CADASIL patients of different…
Primary objective:To evaluate the effects of a training program on physical fitness, energy cost of locomotion and daily physical activity in ambulatory children and adolescents with Spina Bifida Secondary objectives: (1) evaluate physical fitness (…
We therefore set out to study the relationship of LCAT with atherosclerosis using 3.0 Tesla MRI mean wall area (MWA) measurements of the carotid arteries as a marker for atherosclerosis in a cohort of LCAT mutation carriers and compare them to…
Objective of the study: The main objective of this study is to investigate the influence of different genetic mechanisms (risk genes, CNVs and gene expression profiles) in ASD and to study the relation between the genetic heterogeneity and specific…
The proposed study will focus on newly diagnosed breast cancer patients who, prior to receiving treatment, are identified on the basis of age or family history of breast or ovarian cancer as having at least a 10% risk of carrying a mutation in the…
The objective of this research is to develop a method which can identify among all consanguineous couples the ones which are at high risk.
Primary: Dose finding for a twice daily regimen for PSZ as prophylactic treatment in children with CGD, based on the exposure to PSZ measured by PSZ trough levels.Secondary:To determine the tolerability of PSZ as prophylactic treatment in children…
1. To evaluate the consequences of the diagnosis of a sexchromosomal abnormality during routine prenatal diagnostic testing, in the course of which the experiences of the parents and professionals involved will be noted.2.To determine if it would be…
The primary objective of the present study is to increase our insight in the neural processing of speech in pre-lingually deaf CI patients regarding the prediction and explanation of postoperative differences in performance within this specific…
The first aim of this study is to extend clinical knowledge on Sanfilippo syndrome. This has several important reasons:*Clinical knowledge helps the physician to provide better care to patients diagnosed with this incurable disease and to counsel…
The research strives for a large group of homogeneous AID patients, so that a powerful association study can be performed to detect genetic risk factors. These factors can be shared by several AIZ, or be specific is for a single AID. The aim of this…