1540 results
The VIDEOGO-trial aims to assess whether video consultation (VC) is non-inferior to face-to-face (F2F) consultation in terms of 1) patient satisfaction and 2) information retention regarding the pre-operative consultation for complex…
The aim of this study is to investigate the effect of two distalisation techniques of a gastric bypass in revisional surgery with standardised limb lengths in total weight loss (TWL) and the need for treatment for protein calorie malnutrition (PCM…
The project proposed here aims to leverage recent advancements in fMRI methodology and lucid dreaming induction strategies to investigate brain networks and connectivity during REM sleep and its associated lucid vs. non-lucid dream experiences.
We aim to perform an in-depth investigation into the role of the mucosal immune response in the pathogenesis of rheumatoid arthritis. Our objectives are to study the presence of RA-specific autoantibodies and several other biomarkers (cytokines,…
This study aims to phenotype and endotype bronchiectasis during stable disease and exacerbations, to develop strategies for personalised medicine.3.1 Primary ObjectiveTo determine molecular endotypes of bronchiectasis which can guide response to…
The HemaTrate Blood Filtration System is commercially available and indicated for the rapid preparation of a TNC concentrate for use in human cell therapy applications. This study is designed to obtain the data needed to support a new, specific…
The two main objectives are: A) identify patterns of psychofysiological stress in staff and clients prior to challenging behaviour, and B) explore possibilities of biofeedback on the psychofysiological stress level of staff, and whether biofeedback…
Our main objective is to develop and validate body fluid biomarkers that detect CAA in Alzheimer*s Disease patients during life.
To assess accuracy of 18F-sodiumfluoride (NaF) positron emission tomography (PET) and serum non-oxidized parathyroid hormone (PTH) as an accurate, reliable and easy applicable diagnostic tools for the assessment of bone turnover in chronic kidney…
To study the effects of in vitro culture conditions, such as different culture media or oxygen tension, on omic layers (i.e. genome, epigenome and transcriptome) of preimplantation human embryos and to relate this to chromosoom instability (CIN).
Determining the robustness of [18F]-FDG PET/CT based quantitative features in metastatic melanoma patients by test-retesting [18F]-FDG PET/CT scans and varying post processing scan settings, for future diagnostic and prognostic clinical application.
Therefore, in this study, we would like to investigate the clinical effectiveness of a smart technology intervention (The Heart Failure Box) in heart failure patients from the department of Cardiology at Leiden University Medical Center.
The purpose of this trial is to demonstrate proof of concept of clinical activity of BI 1015550 on the change of Forced Vital Capacity (FVC) between baseline and 12 weeks. New treatments are needed that further reduce the decline in FVC, positively…
The primary objective is to determine the safety, tolerability and preliminary efficacy of repeated intrathecal administration of NurOwn® (MSC-NTF: Autologous Mesenchymal Stem Cells [MSC] Secreting Neurotrophic Factors [NTF]) given three times at…
To determine if stimulated salivation during the biodistribution of PSMA-ligands causes a significant increase in the accumulation in salivary glands
The purpose of this study is to evaluate the effect of low-load BFR therapy on quadriceps and hamstring strength 8-, 14-, 26-, 39- and 52-weeks after BPTB ACL reconstruction compared to placebo BFR therapy and conventional HLR training.
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
We examine how a combination of these two physical stressors affect cognitive performance and (subjective) feelings of cognitive (over)load, and which mechanisms are associated with the anticipated decline in performance. Although effects of heat…
The main objective of this study is to compare the acute effects of methylphenidate on behavioral and cognitive functioning in 6 to 12 year old treatment naïve children compared to the effects after nine months of treatment with methylphenidate in…
Our hypothesis is that pedSS has a different presentation and pathophysiology than adult SS, with more genetic involvement. To test this hypothesis, we define the following specific aims: define disease presentation of children with SS-like…