1210 results
Primary: To evaluate the long-term safety and tolerability of BIIB017 in subjects originally treated in Study 105MS301 who continue BIIB017 treatment.Secondary: To describe long-term MS outcomes in subjects originally treated in Study 105MS301 who…
To investigate both the clinical and economical(-healthcare evaluation) improvement of BVR using best responder criteria in patients with severe COPD.
The objectives of this study are to investigate: - which strategies patients use to maintain gait stability and gait adaptability; - whether the strategies used by patients to maintain gait stability and gait adaptability, differ from strategies…
Primary Objective: What are the consequences of irradiation for the human jaw bone and oral mucosa on a macroscopic, microscopic and molecular level?Can possible prognostic factors be identified for the occurrence of peri-implantitis, dental implant…
Primary Objective:Proof of concept study designed to document the safety and feasibility of adjuvant treatment with the PICSO Impulse system in patients with acute anterior ST-segment elevation myocardial infarction (STEMI) treated with primary PCI…
Primary Objective During Double-Blind Period:To compare the efficacy of BMS-945429 SC versus placebo on a background of methotrexate as assessed by ACR20 response rates at 12 weeks.Secondary Objectives During Double-Blind Period:1) To assess…
The goal of this pragmatic, randomized controlled study is to determine the effectiveness of two relaxation techniques, eg. TM or HT added to the treatment of paediatric primary headaches in comparison to standard medical treatment (SMT). TM or HT…
To determine if HF subjects whose treatment is assisted by a daily BNP measurement that is integrated into a home health management system will have improved clinical outcomes versus subjects whose treatment includes home health management but is…
Primary Objective: The main objective of this study is to demonstrate that PVC suppression therapy on top of conventional heart failure treatment improves cardiac systolic function as assessed by quantitative echocardiography in patients with…
We would like to investigate if we can develop a biomarker test that enables us to identify patients that will respond to therapy or not before start of therapy. Research will be focused on ex vivo studies with whole blood that will be treated in…
Primary: progression-free survival in the GSK1120212-group in comparison with the docetaxel group. Secondary: safety and tolerability, response rate, duration of response, overall survival, PK.
Primary:The primary objective of the study is to evaluate the efficacy of oral administration of dexpramipexole 150 mg twice daily compared to placebo for 12 months in subjects with ALS.Secondary:The secondary objectives of the study are to evaluate…
The main aim of the present study is to improve our understanding of the role of blood-brain barrier function and cerebral perfusion in dementia of the Alzheimer*s type.
The objective of the study is to evaluate the safety and efficacy of eculizumab to prevent AMR in sensitized recipients of living donor kidney transplants requiring desensitization therapy.
To evaluate in detail the functionality of immune cells in the liver and blood in chronic HCV patients before, during and after treatment with telaprevir, pegylated-IFN-alfa and ribavirin.
The primary study objectives are: (1) to determine whether an internet-based guided self-help intervention is effective in reducing symptoms of depression in glioma patients; (2) to determine the impact of the intervention on the HRQOL of both…
This study will answer the question if (repeated) abdominal amnioninfusion after midtrimester PPROM with associated oligohydramnios improves perinatal survival and prevents pulmonary hypoplasia and other neonatal morbidities. Moreover, it will…
The primary objective is to determine the number of subjects that experience a decrease in CDAI (Crohn*s Disease Activity Index) of at least 70 points by the Week 8 or Week 12 assessment.
To assess the short-term (2 hours, and 2 days) effects of the egg protein hydrolysate on arterial stiffness in volunteers, aged 18-70 years with overweight and impaired glucose tolerance (defined as blood glucose >7.0 mmol/l and <11.0…
Evaluation of the feasibility of sentinel node detection by PET-CT lymphoscintigraphy