20 results
The primary purpose of the study is to investigate whether the new 20 mg capsule of Orfadin® (nitisinone) has a similar bioavailability in the body (gives the same concentration in the blood) as two of the marketed capsules of 10 mg. The secundary…
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
The prime objective of the proposed study is to apply treatment modeling for superficial hyperthermia in a well-defined group of patients to investigate the potential of predicted 3-dimensional energy as source for a dose parameter that is…
• To estimate the difference in the efficacy and safety of RAD001 10 mg p.o. daily dose in combination with bevacizumab 10 mg/kg administered intravenously every two weeks for first-line treatment of patients with metastatic carcinoma of the kidney…
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
Objective: The primary objective of the study is determining the contributing factors in bracing for AIS. The contributing factors are determined as factors of influence in the corrective possibilities and therefore end term…
To determine the musculoskeletal safety of standard prophylactic treatment with ciprofloxacin and co-administered glucocorticoids in pediatric patients with acute lymphoblastic leukemia (ALL).
Adequate perfusion of an adult-sized renal graft in children demands significant hemodynamic changes after transplantation (Tx). Suboptimal renal graft perfusion due to inadequate hemodynamic adaptation increases the risk of loss of renal graft mass…
Primary Objectives: -To evaluate if the treatment of Low Risk HB can be reduced (Group B1) -To compare different induction treatment regimens for Intermediate risk HB (Group C) -To compare different post induction treatment regimens for…
We hypothesize that the inter-observer variability of the CPR, MCA, UA and UtA measurement will be less than intra-observer variability due to normal biological variation of cardiovascular control.
Bone-anchored maxillary protraction therapy improves facial profile in cleft children.
1) the OST is superior to the 3-weeks waiting period 2) the OST+app is superior to the OST-only at post-treatment and at follow-up
The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancer SECONDARY OBJECTIVES: To assess in children with cancer after SARS-CoV 2 vaccination: - durability of…
A decrease in the incidence of central line-associated bloodstream infections in the investigational study group, compared to the control group.
Vapor ablation can effectively and safely eradicate short BE segments
Objectives: 1) to evaluate the effectiveness of the e-CBT-i “i-Sleep” compared to a waiting list condition on sleep efficiency at 3, 6 and 12 months in ACC. 2) to assess the effects of eCBT-I on secondary outcomes: fatigue, quality of life, chronic…
The primary objective is to measure the effect of nociceptive stimuli on features derived from ECG, ABP, PPG, EEG and facial video recordings, to be used to design an index of nociception. The index of nociception should correlate well with strength…
The objective of the PANDORINA trial is to evaluate the non-inferiority of omitting routine intra-abdominal drainage after DP on postoperative morbidity (Clavien-Dindo score ≥ 3), and, secondarily, POPF grade B/C.
We hypothesize that implementation of ambulatory cPNB for postoperative analgesia in lower limb surgery will be non-inferior regarding patient-reported overall benefit of analgesia, when compared to standard care for pain control using sPNB and…