7320 results
Primary objective: Are changes in stress-induced autonomic and hormonal parameters associated with (epi)genetic vulnerability for schizophrenia and bipolar disorder?Secondary objectives: 1. Are changes in autonomic and hormonal parameters after…
PRIMAIRYThe primary objective of this trial is to evaluate the efficacy of atacicept compared to placeboin preventing new flares in subjects with SLE.SECONDARYSecondary objectives of the trial are:• To evaluate the safety and tolerability profile of…
The primary purpose of the study is to investigate whether the new 20 mg capsule of Orfadin® (nitisinone) has a similar bioavailability in the body (gives the same concentration in the blood) as two of the marketed capsules of 10 mg. The secundary…
• To estimate the difference in the efficacy and safety of RAD001 10 mg p.o. daily dose in combination with bevacizumab 10 mg/kg administered intravenously every two weeks for first-line treatment of patients with metastatic carcinoma of the kidney…
The prime objective of the proposed study is to apply treatment modeling for superficial hyperthermia in a well-defined group of patients to investigate the potential of predicted 3-dimensional energy as source for a dose parameter that is…
1. Dutch patients with Addison's disease treated with suboptimal glucocorticoid replacement therapy have a reduced QoL; 2. Prevalence of the metabolic syndrome is higher among patients with Addison's disease treated with suboptimal…
Usage of SDD or SOD has been shown to reduce the incidence of ventilator associated pneumonia (VAP) and to improve patient survival. SDD and SOD were shown not to increase resistance of bacteria colonizing the digestive tract. It can not be excluded…
Exercise training in the fasted state might be a more effective strategy to maximize glycemic control in T2DM patients, as opposed to exercise training in postprandial state.
MRD detection using next generation sequencing (NGS) on circulating tumor DNA (ctDNA) from PTLD patients using a gene panel previously used in diffuse large B-cell lymphoma (DLBCL) may be feasable
Administration of magnesiumsulphate has the potential to elicit muscle relaxation. We hypothesize administration of intramuscular magnesiumsulphate can reduce CRPS-related dystonia.
Poor sleep is a potential risk factor for impulsive and aggressive behavior. Our hypothesis is that treatment of sleeping problems in forensic psychiatric patients ameliorates sleep and general psychopathology, and reduces impulsivity and aggression…
Primary aim of the randomised trial is to elucidate the efficacy of, respectively, Oral Appliance (OA) and Continuous Positive Airway Pressure (CPAP) therapy in the management of the Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). It is…
The primary hypothesis is that attentional bias modification (ABM) training towards and away from pictorial itch stimuli results in altered attention for pictorial itch stimuli. Secondarily, it will be explored whether attentional bias modification…
Muscle weakness in patients admitted to the Intensive Care Unit lengthens duration of mechanical ventilation, weaning and hospital stay. One of the causes for muscle weakness is critical illness polyneuromyopathy (CIPM). The incidence of CIPM varies…
Overweight and childhood obesity are still serious health problems, especially among children from families with lower socio-economic status (SES). Current obesity prevention programs are often not focussed on children’s first years of life,…
Reinforcement with prophylactic slowly-resorbable TIGR Matrix mesh in high-risk patients undergoing midline laparotomy is effective.
1. Is there, by using a vaginal tampon, less postoperative bleeding?; 2. Are there, by using a vaginal tampon, less postoperative infections?; 3. Is the result of prolapse surgery negatively influenced by not using a vaginal tampon?; 4. What kind of…
1. It is feasible to perform lymphatic mapping in locally advanced uterine cervical cancer. 2. There are lymph nodes on the lymphatic map which are not included in the radiation treatment plan or did not receive sufficient radiation dose.
A guided app-based modular intervention (monitoring + intervention) is more effective than monitoring only in preventing relapse of anxiety and/or depression (in terms of time to relapse) in recovered youth aged 13 – 21 years up to three years…