3306 results
The aim of the study is to understand the nutritional status of people with complex multiple disabilitiest through measurement of body composition and nutritients.The primary objective of the study is:What percentage of people with complex multiple…
To study the effects of transient severe endogenous stress hormone exposure on the structure and functioning of brains circuitry regulating emotion, and the association with cognition and psychopathological symptoms.
The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…
The primary objective of this study is to gain more knowledge about the mean and the distribution of mitochondrial oxygen tension (mitoPO2), the mitochondrial oxygen consumption (mitoVO2) and the affinity for oxygen of mitochondrial respiratory…
The primary objective of this study is to investigate whether CYP3A phenotype, as measured with midazolam clearance, correlates with cabazitaxel clearance. Our secondary objective is to investigate whether this CYP3A phenotype outperforms BSA as a…
Knowledge about the physiological metabolism of SCFAs and the interorgan exchange of SCFAs across different abdominal organs in humans is lacking to some extent.To this end, the following objective will be addressed in the current study: -Determine…
The research focuses on the active screening of high prevalence patients and the diagnosis of AAA. This study aims to establish an effective screening protocol and determining a higher prevalence in patients with PAD and patients with carotid…
To determine prevalence of HPV infection before and after renal transplantation. Secondary objectives are to determine the incidence of HPV infections before and after renal transplantation and the genotype of the HPV infections per time point, and…
Primary objective: To investigate whether sleep disturbances during pregnancy and/or in the perinatal period will predict postpartum psychopathology in women with an established diagnosis of bipolar disorder and/or a history of postpartum psychosis.…
Objective 1: to examine the relation in wall thickness and diameter across arteries that are prone (i.e. carotid, femoral, superficial femoral and popliteal) and resistant (i.e. brachial and radial) against atherosclerosis in healthy volunteers and…
We have set prior to the design and implementation of this research a primary and a secondary goal.Primary goal:Testing the validity of the computer model of the coagulation cascade and the related PK / PD model of VKA and heparin for use in…
Clinical, prospective, non-randomized trialOrbis Medsich Centre, Sittard-Geleen
The gaol of the present study is to determine the role of platelet derived TFPI on coagulation in healthy male subjects (n=10) and in healthy female subjects either using ( n=10) or not using oral contraceptives (n=10). Additionally 8 healthy…
The mission of CHEAP is to evaluate whether a protocol can be developed that enables the GP to detect patients with primary hypertension who are at risk for developing future heart failure.The European Society of Cardiology has recently (2008)…
The ultimate goal of this research is the clinical implementation of a non-invasive test for prenatal fetal genotyping, including fetal sex determination, using cff DNA in maternal plasma, to replace the current standard practice of invasive tests,…
Our primary aim is to develop en perfection the diagnostic accuracy of the non-invasive tests for chromosomal aberrations in maternal blood.
Therefore, the aim of this study will be to assess reproducibility of pseudo-CASL (p-CASL) between 3.0 Tesla MR scanners of two vendors in two medical centers.
We propose to perform a pilot study to examine the feasibility of studying the triangular association between: 1) amino acid metabolism (influenced by, amongst other factors, diet composition [e.g. energy intake, macronutrient intake, individual…
To examine cellular damage, intestinal barrier function loss, activation of the Complement system and inflammatory alterations induced by ischemia and reperfusion of the human small and large intestine.Second, we aim to study the consequences of…
Examine the effects of a single meal on BAT activation and intrinsic mitochondrial uncoupling in SM in lean and obese individuals, and define the role of the SNS within this response.