831 results
The primary objective is to determine the impact of HER2 expression in CTCs taken at baseline on outcome to AIs in metastatic breast cancer patients with an ER-positive primary tumor. Secondary objectives are to determine impact of HER2 expression…
The purpose of the Endurant Evo International Clinical Trial is to evaluate the safety and effectiveness of the Endurant Evo AAA Stent graft system for endovascular treatment of subjects with infrarenal abdominal aortic or aortoiliac aneurysms.
Primary objective is to gain insight into risk acceptation of serious adverse events (<30 days) in bariatric surgery. Secondary objectives are the expected weight loss, risk acceptation of mortality, risk acceptation of serious adverse events…
The aim of this study is to investigate the differences in organ-specific protein turnover rates by means of stable isotope labelled amino acid infusion in patients undergoing surgery. Primary objective:To compare protein synthesis rates, expressed…
* To estimate the prevalence of hyposalivation and xerostomia in pediatric cancer survivors treated with different cancer regimens (e.g., H&N RT, TBI, CT, or those who developed cGVHD following allogeneic stem cell transplantation).* To…
In patients with neoadjuvant disease the purpose of the study is to define the safety and tolerability of the drug. In patients with metastatic disease the purpose is to determine if treatment with Nivolumab or Nivolumab and ipilimumab will lead to…
Primary objectives* To assess the tolerability of regorafenib combined with paclitaxel.Secondary objectives* To assess the effect of regorafenib on uptake of paclitaxel in OGC metastases.* To assess the effect of regorafenib on regorafenib targets…
To determine the activity of nivolumab after four different immune response induction treatments in TNBC patients with metastatic disease. We hypothesize that short-term induction treatment induces an anticancer immune response resulting in…
The objectives of this open-label extension*safety monitoring (OLE-SM) study are as follows: Part 1 (Open-Label Extension; OLE) • To assess the long-term safety and efficacy of etrolizumab in patients eligible for Part 1 (OLE) Part 2 (Safety…
if at least 50% of the obtained tumor samples will be viable and proliferating after 14 days (i.e. proliferation rate at day 14 is at least 50% of the proliferation rate at day 0), the ex vivo model will be considered as feasible
Objectives for Part A1 Monotherapy Dose EscalationPrimary Objective:* To assess safety, and tolerability at increasing dose levels of PF 04518600 in patients with selected advanced or metastatic solid tumors in order to establish the MTD.Secondary…
The primary objective of this prospective open label study is to assess the ability of vedolizumab to promote clinical, endoscopic and histological remission in patients with active UC in an 'early' and a 'late' disease…
DDAVP treatment combined with FVIII clotting factor concentrates in patients with mild hemophilia A.
Primary objectives:To assess the proportion of non-severe hemophilia A patients within FVIII target levels with the DDAVP and FVIII concentrate combination treatment in the first 72 hours after the start of combination treatment, without adding off-…
The primary objectives of this study are: 1. To examine the effect of cold acclimation on cardiovascular risk parameters in type 2 diabetic patients. 2. To study if the previously observed effect of cold acclimation on insulin sensitivity in type 2…
This study aims to investigate, using a prospective, longitudinal outcome study design to assess the use of REGENOSS in attaining spinal fusion in patients requiring single-level or 2 level Posterior Interbody Fusion of the lower lumbar spine.See…
The main goal of the study is to assess the incidence of respiratory events using the IPI device.
The primary objective is to evaluate the antitumor activity of ceritinib in patients with ALK-positive NSCLC metastatic to the brain and/or toleptomeninges based on whole body overall response rate (ORR), defined as the proportion of patients with a…
Primary Objective: Identification of patient characteristics, echocardiographic measurements and biomarkers that can contribute to a better selection of patients that benefit from percutaneous ASD closure at adult age. Secondary Objectives:-…
A) To investigate the pharmacokinetics and determinants of MTX-PG accumulation in plasma and erythrocytes in adult CNS lymphoma and leukemia patients treated with HD-MTX;B) To investigate whether intracellular MTX levels are related to toxicity in…
Obtain normative data within similar age-range as our clubfoot patients.