800 results
To investigate if the use of different stimulation protocols / GnRH-analogues affects embryo developmental kinetics after IVF treatment. We hypothesize that GnRH analogues differentially affect embryo development through differences in follicular…
The major objective is to investigate the effects of the GR polymorphisms on metabolism in the skeletal muscle, in order to unravel the pathophysiological mechanisms underlying previously observed clinical effects in carriers of this polymorphisms.…
The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…
The study is primarily designed to compare the clinical outcome between the TM transfer and the LD transfer in patients with a massive posterosuperior rotator cuff tear. Our secondary objective is to asses the quality of life in patients undergoing…
The primary aim of this study is to gain knowledge on the natural course of Dupuytren's disease, in adults with various Dupuytren disease stages. Secondary aims are: - Gain insight in course after treatment- Determine whether there are risk…
Primary Objective• To assess the safety and tolerability of long-term tofacitinib therapy in subjects with UC.Secondary Objectives• To evaluate the efficacy of long term tofacitinib therapy in subjects with UC.• To evaluate the effect of long term…
To study phenotypic and functional characteristics of hepatic lymphocytes in patients with viral hepatitis or other liver related diseases.
To study the safety of the adoptive transfer of autologous T cells modified with a Mart-1 specific TCR in advanced stage (uveal) melanoma patients with disease progression upon standard cancer therapy. In addition, the toxicity according to CTC…
Primary objectives Phase Ib: To estimate the MTD and/or RP2D of LGX818 in combination with cetuximab ± BYL719. Incidence of dose-limiting toxicities (DLTs). Phase II: To compare the efficacy of the dual (LGX818, cetuximab) and triple (LGX818, BYL719…
Primary objectives are:To assess the diagnostic accuracy of DWI in the evaluation of disease activity in JIA as compared to contrast-enhanced MRI as the reference standard.To assess the accuracy of DWI in detecting joint inflammation as compared to…
* To establish the safety profile of daratumumab when given in combination with lenalidomide and dexamethasone in subjects with relapsed or relapsed and refractory MM
Primary Objective: Evaluate the safety of the combination of pomalidomide (POM) and low dose dexamethasone (LD-DEX) in a large cohort of subjects with refractory MM or relapsed and refractory MM.Secondary Objectives:- Analyze the population…
Primary objective To determine the relation between age and pharmacokinetics of docetaxel, paclitaxel, doxorubicin, gemcitabine, vinorelbine and capecitabine, respectively. Secondary objectives All here cited secondary endpoints will be separately…
To assess toxicity of MRI guided high-dose-rate focal brachytherapy as monotherapy for favourable risk prostate cancer. As secondary objectives, technical feasibility, quality of life and biochemical free survival will be determined.
Primary: to determine whether an early psychological intervention poststroke in order to reduce symptoms of anxiety and depression, is feasible.Secondary: To evaluate if an early individual psychological intervention in patients independent in…
The PRELHUDE study investigates the reversal of the ZAHARA3 study; whether subclinical congenital heart disease occurs in women who deliver prematurely for unknown reason. The biosamples taken during and after delivery will be used to determine…
The aims of the present study are: 1. to create a tracer kinetic model for quantification of [18F]FCH and simultaneously validate a simplified quantitative method, and 2. to assess the repeatability of the latter method.
The goal of this investigation is to show that Hemospray is effective in achieving initial hemostasis rates equivalent to standard of care treatment and a decreased rate of further bleed when compared to standard of care up to 72 hours after…
We want to describe in detail the MTH-induced changes in pro- and anti-inflammatory markers in patients after CA. We further aim to evaluate the relation between neurological outcome and levels of pro- and anti-inflammatory markers.
The objective is to sequentially test, validate, obtain regulatory approval for, and deploy at home, a closed-loop Control-to-Range (CTR) system comprising two algorithmic components: a Safety Supervision Module (SSM) and an automated Range…