763 results
To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…
Primary To determine the maximum tolerated dose (MTD) and characterize the dose-limiting toxicities (DLT) of LEE011 when administered orally once daily for 21 consecutive days followed by a 7 day break.Secondary *Safety and tolerability of LEE011.*…
The objective of this extension study is to find out the potential long-term benefits and safety of tolvaptan. During this study all participants will receive tolvaptan.PRIMARY OBJECTIVE is to demonstrate whether tolvaptan modifies ADPKD progression…
* To study the relationship between inflammation on MRI and syndesmophyte formation with very detailedimaging methods: radiography, computed tomography (CT), 3 and 7 Tesla MRI. * To examine the time order of pathologic changes like inflammation,…
Proof of principle of imaging the polyamine concentration with 7 Tesla 1H-MR spectroscopic imaging in patients with prostate cancer
To study the quantitative and qualitative relationship between a heat stimulus and the vasomotor response in healthy subjects and to determine the feasibility of this measurement setup for patients.
The aim of this project is to assess whether 4D-CTA can generate 3D cranial image data sets with sufficient spatial and temporal resolution to enable its use as a diagnostic tool in cerebrovascular pathology and physiology such as arteriovenous…
The primary objectives of this study consist of:1. To assess the accuracy of different pulse contour methods to measure CO compared to thermodilution CO measured with a PAC in major abdominal surgery patients.2. To assess the effect of propofol…
Primary Objective: To study the arginine-NO metabolism during fracture healing and dysfunctional fracture healingSecondary Objective(s): To investigate if differences or decreased arginine and NO concentrations in bone healing form a prognostic…
To compare the effectiveness of PVI and VATS-PVI. Secondary objectives are to compare the duration of hospitalisation, quality of Life, cost and to compare the satisfaction of the patients.
The objective of the study is to determine the effectivity of this consolidation treatment, as well as the conversion rate of PR to CR in patients in PR before consolidation and the effect on the immunological recovery.
To evaluate the long term safety, efficacy, predictability, stability, complications and patient satisfaction after implantation of Artisan phakic intraocular lenses for the correction of high degree myopia.
The present research protocol aims at the development and implementation of a valid self-report instrument for suicidality amongadolescents. The instrument needs to be invariant for ethnicity and needs to register fluctuations in suicide risk and…
1. To construct a Dutch multicenter prospective biorepository for validation of biomarker and imaging products.2. To provide a Medical Technology Assessment (MTA) of newly developed biomarkers, contrast enhanced ultrasound and multimodality MR Iin…
Zie pagina 39-40 van het protocol MO22923 versie 2, 26 Mei 2011
The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…
To assess the percentage of patients with at least one subtherapeutic infliximab trough serum concentration, being < 1 mg/l.To assess the percentage of patients positive for AIAs at a minimum of one timepoint.To assess the percentage of…
To investigate the dynamics of tumour hypoxia as assessed by 18F-FAZA PET/CT during and after chemoradiotherapy. To investigate the best strategy to deliver a boost dose to the hypoxic tumour areas. This strategy may be either a simultaneous boost (…
To investigate the hypothesis that temporising treatment of women with early-onset, severe preeclampsia improves infant outcome and may reduce direct treatment costs in comparison to short-term planned delivery, while persistent maternal morbidity…
The primary objective of this study is to evaluate the PK of POS administered orally at three dosage levels to immunocompromised children with expected neutropenia (selected oncology patients, aplastic anemia patients and patients which undergo a…