97 results
Primary objectives: 1. Assess the feasibility of FMT in PD patients. 2. Assess the safety of FMT in PD patients. Secondary objectives: 1. Explore whether FMT leads to alterations in motor complications (fluctuations or dyskinesias) and…
Primary objective: To classify the effect of the pharmacogenetic profile of CYP2C19 and CYP2D6 in HD gene expansion carriers on negative medication effects of HD-related medication with an actionable drug-gene interaction in the…
Evaluation of the effect of treatment with the Meniett in patients with unstable Menière*s disease.
To determine the incidence and grade of venous emboli and/or paradoxical gas emboli during hysteroscopy surgery using TOE. In addition, a comparison will be made using either bipolar or monopolar diathermia. Knowing the incidence and severity of…
The objective of this study is to determine which operation technique is better in terms of pain, physical function, range of motion, strength and complications.
Primary Objective: What is the frequency of positive patch test reactions to the 26 declarable fragrance allergens in fragrance mix I and/or II positive participants?Secondary Objectives: Do Weleda cosmetic products containing essential oils,…
The primary objective of this study is to determine whether ACE inhibition results in an improvement of microvascular glycocalyx-thickness in patients with type 1 diabetes. The secondary objectives are to investigate whether this (hypothesized)…
To investigate the effects of beclomethasone plus formoterol (in a single inhaler) versus single agents formoterol and beclomethasone dipropionate pMDI with HFA-134a propellant and placebo on the airway responses to allergen challenge. The primary…
The main purpose of the study is to compare the absorption of MK-7 from casein capsules (conventional MK-7 delivery system), Arabic gum capsules (alternative MK-7 delivery system), and linseed oil capsules in healthy subjects. The primary endpoint…
Primary aim of the study is to compare the efficacy and safety of two flowrates of ITB while maintaining a constant daily dose.
Primary • To investigate the safety and tolerability of long-term treatment with 1.5 mg or 3.0 mg of Org 50081 in elderly outpatients with chronic primary insomnia. Secondary • To collect exploratory efficacy data of long-term treatment with Org…
Striatal D2 receptor availability will be ascertained in 30 recent abstinent cocaine addicts by [123I]IBZM SPECT. In addition, we will measure drug craving and impulsivity with questionnaires, fMRI/EEG using cue-reactivity and impulsivity paradigms…
The purpose of this study is to evaluate the safety and effectiveness of adalimumab for the treatment of moderate to severe Crohn*s disease in children between 6-17 years of age. In addition, information will be collected to select the most…
To evaluate the potential attenuating effects of a one-week supplementation with 2 x 250 mg caffeine per day on blood biomarkers of systemic inflammation in COPD patients.
The aim of the study is to investigate the effects of atomoxetine on driving performance compared to placebo in 30 adult patients with ADHD. An auditory oddball paradigm will be presented and EEG will be measured during driving to gain insight in…
The study is performed in order to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia in the morbidly obese patient (BMI > 40). A covariate analysis will be…
The main objective of the study is to find an instrument that can be used to objectively establish improvement in adults with ADHD with treatment with OROS-Mph, so that adherence to treatment can be increased and so that patients and docters can…
The objective of the study is to establish the effect of genestein in patients with MPS III on urinary and serum GAGs levels, hair morphology, GAG accumulation in skinbiopsy, cognitive functions and behavior (Piotrowska et al, 2008).MPS III is a…
In this study we will investigate whether there is cross tolerance for the effects of alcohol and cannabis. Therefore we will investigate both the pharmacodynamic and pharmacokinetic effects of a combined administration of cannabis and alcohol.
The purpose of the present study is to obtain a pharmacokinetic profile of ropivacaine in serum with epinephrine, and of ropivacaine in serum without epinephrine, used for high dosed combined femoral and sciatic nerve block in lower extremity…