1562 results
The above anounced studies suggest that some abnormalities in the Wnt pathway can be expected to affect development and function of the brain, potentially leading to recognizable behavioural phenotypes. Given the key role of APC in the Wnt pathway,…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The proposed studies will investigate the effect of auditory attention on speech comprehension, its relation to listening effort, and the effect of hearing loss on these processes.
1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…
The project consists of three concrete goals:1)Compare symptoms and patterns of fatigue of visually impaired adults with a control group of adults without a visualimpairment.2)Develop an intervention aimed at treating symptoms of fatigue in visually…
High-field (7T) MRI and genetic biomarkers for neurocognitive impairment in type 2 diabetes melltius
The primary objectives: 1. To tailor and apply high-field multi-parametric and functional MRI techniques to identify cerebral biomarkers in DM2 and MetS patients compared to control subjects.2. To examine a specific set of genetic hypotheses in DM2…
Main objectiveTo investigate whether dopamine affects the ability to initiate the correct step in response to a sudden change (improbable picture in a predictable context) in PD with and without FOG. Secondary objectiveTo investigate whether…
The objective of this study is to analyse the retinal oxygenation in adults with the Oxymap T1 in patients with amblyopia and untreated or treated (vitreo-) retinopathies and compare them to a reference group of healthy eyes of amblyopic and Coats…
The main goal of the VUmc part of the study is to acquire sets of data related to Neurological and Neuromuscular Diseases; in order to build a paediatric digital repository and to develop biophysical modelling and probabilistic modelling.
The main objective of this pilot study is to determine if 31P MRS and BOLD-MRI or 1H MRS can be used as diagnostic tests to discriminate between ischemic muscle and normally oxygenized muscle and to assess their reproducibility.
The primary objective of this study is to demonstrate that free field word recognition scores in quiet and noise with CI *ON* are significantly better than the best aided pre-implant scores in the ear to be implanted (contralateral ear plugged)…
To determine the relationship between phenotypic, genetic and biochemical features of AD. , Relevant bimarkers of the skin barrier function including the levels of NMFs, inflammatory mediators (e.g. IL-1 cytokines), SC lipids and serine proteases…
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
This study is part of a prospective cohort study in the University Medical Center Groningen aimed at the determination of prognostic factors for outcome of children with TBI. The study is a pilot study to determine the value of fNIRs for detection…
Determine the repeatability, inter and intra-observer variability of the *Scolibed*. Determine the variation in stiffness for healthy individuals and for scoliotic patients. Compare the results of healthy individuals and scoliotic patients.
The primary objective of this study is to assess the association between pre-dialysis comprehensive geriatric assessment and early death or withdrawal from dialysis (<6 months) in patients aged over 65 years
The main objective of this study is to determine the neural correlates of apathy. These neural correlates will be compared with the neuropsychological tests At a later stage, the predictive value of the neural correlates will also be assessed.
With this research we intend to fill the gap described in the previous chapter by:1) Detecting functional network changes in several causes of early-onset dementia and to characterize the specific changes for each dementia cause.2) Relating specific…
The objective of this study is to investigate whether the differences in DNA methylation between individuals who were exposed in utero to the Dutch Hungerwinter (F1) and their non-exposed, same-sex siblings (F1) - as identified in epigenome-wide…
1. To determine the reproducibility of the ECWT and the 6MWT to assess the physical strain of walking in patients with PPS and in healthy control subjects.2. To evaluate the one-year course of the physical strain of walking among patients with PPS…