1095 results
To compare the overall survival of ipilimumab monotherapy at doses of 3 mg/kg versus 10 mg/kg in subjects with previously treated or untreated unresectable Stage III or Stage IV melanoma
In previous studies, the chronic effect, up to 6 months, of the one gastric lead continuous stimulation was demonstrated resulting in an improvement in blood glucose levels. The present hypothesis is that this effect is mediated by either a…
Primary ObjectivesIn patients with primary hypercholesterolemia and high cardiovascular risk with LDL-C >=100 mg/dL (2.59 mmol/L) and <=160 mg/dL (4.14 mmol/L), to evaluate:1)at the end of Phase I, the additional LDL-C percentage…
This is a active-controlled dose-range-finding study which is also designed to assess the efficacy and safety of preladenant 2, 5, 10 mg twice daily during long term use as an adjunct therapy to L-dopa when administered to subjects with moderate to…
Investigate the effect of adjuvant metformin therapy on insulin need and on glycaemic control in CFRD patients.
We would like to conduct a multicentre randomised controlled clinical trial to compare the difference in early postoperative pain after unilateral primary inguinal hernia repair in males. The procedures will be performed in day surgery. Early…
In this trial the outcomes of an Ultrapro mesh after endoscopic hernia repair (TEP) will be compared with the outcomes of a heavyweight mesh (Prolene) after TEP hernia repair. The primary objective is to determine the effect of a lightweight mesh (…
To assess the efficacy and safety of two Pasireotide LAR regimens in CD patients.
The purpose of this clinical trial is to demonstrate the safety and efficacy of the Z-Lig* device for the treatment of ruptured ACL of the knee compared to allograft.
The primary research inquiry being raised concerns anaesthesia related causes:Is it possible that adapting an amount of sevoflurane, from 1 MAC (minimum alveolar concentration) (2,5 vol%) to * MAC (1,25 vol%) in an MRI scan can reduce the frequency…
The primary objective is to examine the efficacy of the memory-strategy training for treatment of mild memory impairments in patients with SMC, focusing on memory functions crucial for daily life functioning.Secondary objectives are the subjective…
Compare if once daily laba/lama treatment with two different dosages shows the same or better result on the 24 hr lungfunction than twice daily treatment of two different dosages with ICS/laba treatment. .
Primary objectives:• To evaluate the safety and tolerability of BMS-914143 as measured by the frequency of SAEs and discontinuations due to AEs;• To assess the HBeAg seroconversion rate at 24 weeks off treatment (Week 72).Secondary objective• To…
The purpose of this clinical trial is to demonstrate the efficacy and safety of the Rheos system in subjects with JNC-7 defined stage II hypertension that is resistant to treatment with at least three anti-hypertension agents, one of which is a…
This study is designed to evaluate the safety and performance of SinuBand, a bioresorbablefluticasone propionate-eluting sinus dressing in the postoperative management of FESS in patientswith chronic rhinosinusitis. The study will collect both…
In the proposed study, two main issues will be addressed: first, it will be studied whether a high dose (4.0 mg) of FA supplementation periconceptional has an added value over the now recommended low dose of 0.4 mg in the prevention of congenital…
1) Safety: Non inferiority of the BioFreedom* to the Gazelle* Bare Metal Stent in patients treated with one month DAPT only followed by aspirin alone. The non-inferiority will be assessed by the composite endpoint of CD, MI and ST at 1 year.2)…
To evaluate the impact of electroencephalographic Narcotrend* Index (NI) monitoring on the speed of emergence and recovery from PPS for PGE.
Efficacy and safety.
The primary objective of this study is to demonstrate that the IOP-lowering efficacy of Travoprost Ophthalmic Solution, 0.004% (preserved with POLYQUAD) is noninferior to Timolol Ophthalmic Solution (0.5% or 0.25%) in pediatric glaucoma patients.