102 results
Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…
To investigate the dynamic relationship between hemodynamic responses to different levels of acute SERT occupancy induced by different doses of the reuptake inhibitor (SSRI) citalopram with 5-HT phMRI, as compared to [123I]FP-CIT SPECT imaging.…
Primary Objective: The primary objective is to determine whether the administration of Gelofusine will reduce the kidney uptake of 111In-labeled exendin in humans by enhancing the excretion of 111In-labeled exendin. These highly relevant data can…
The primary objective of this study is to investigate whether serum taken from volunteers subjected to 30 minutes of helium inhalation can protect different cell types against hypoxia-reperfusion induced damage and to investigate the role of…
The main objective is to evaluate the appetite suppressive effect of polydextrose, measured as the Energy Intake at ad libitum lunch (T=240 min) on normal weight and overweight women consuming 12.5 g of polydextrose or placebo in a low-fat yogurt as…
1) To determine whether vaccination with yellow fever results in a higher cytokine response upon restimulation in vitro with non-related infectious pathogens, compared to the response before the vaccination.2) To determine whether BCG vaccination…
This study aims to evaluate the safety, tolerability and sedative proporties of a single dose of intransally administered dexmedetomidine in person odler than 65 years, differentiating between person using beta-blocking medication and those not…
To evaluate the effect of Souvenaid® on cognition in patïents with mild cognitive impairment after 24 months.
PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…
We aim to develop a proxy-model of baseline dopamine based on machine learning methods which would provide us with behavioural predictors of the effects of dopaminergic drugs on brain and cognition that maximally generalize to new participants.
The aim of the present study is to determine the effect of vaccination on anti-oxLDL antibodies in man.
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…
Primary objective- To determine safety and tolerability of a single dose of cRGD-ZW800-1 in healthy volunteers.Secondary objectives- To determine the pharmacokinetics of a single dose of cRGD-ZW800-1 by measuring the fluorescence of blood and urine…
Primary Objective- To evaluate the clinical efficacy and safety of oral apremilast (APR) 30 mg twice a day (BID) compared with placebo, in subjects with moderate to severe plaque psoriasis at Week 16.Secondary Objectives- To evaluate the clinical…
The objectives of the study are to assess whether:(1) SNP will reduce the occurrence of psychomimetic side effects during exposure to low-dose ketamine;(2) SNP will reduce the ketamine-induced increase in blood pressure and cardiac output;(3) SNP is…
Primary* To determine the safety and tolerability of multiple oral ascending doses of FP 025 in healthy subjects.Secondary* To determine the pharmacokinetics (PK) of FP 025 after multiple oral ascending doses of FP 025 in healthy subjects.* To…
To diminish the number of asthma exacerbations with the regular use of a bacterial lysate.
Here we will test the hypothesis that stimulating DLPFC with either rTMS or tDCS during one single session affects the functional connectivity of the DLPFC, and is associated with an increase of activation in connected areas of the cerebrum and…
Primary• To assess the effects of RVT-101 versus placebo on global function as measured by the Clinician*s Interview-Based Impression of Change Plus Caregiver Input (CIBIC+) after 24 weeks of treatment• To assess the effects of RVT-101 versus…
Primary objective:To evaluate the single- and multiple-dose safety and pharmacokinetics of CNM-Au8 upon oral administration of CNM-Au8 to healthy adult male and female subjects.Secondary objective:Exploreing the immune-modulating effects of CNM-Au8…