67 results
Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…
Study Rationale and ObjectivesThe objective of the study is to determine the efficacy and safety of lacosamide, a sodium channel blocker, in patients with pain due to SCN9A-associated SFN. The proposed study plans to recruit patients with clinically…
The main objective of this prospective randomized study is to examine the effect of low-dose radiotherapy on pain sensation in patients with early OA of the hip. Our hypothesis is that radiotherapy can achieve a pain-reducing effect of at least 20%…
The aim of the study is: to investigate the effect of DCS on the physiological and subjective correlates reflecting conditioned sexual response and subsequent extinction thereof. Hypothesis: We hypothesize that administration of DCS after an…
To compare the EEG pattern after administration of cyclopentolate with the EEG pattern after placebo eye-drops.Primary outcomeEEG pattern changes after administration of two drops of cyclopentolate1% compared with placebo.Secondary outcomes- Pattern…
The aim of the study is: to investigate the effect of DCS on the physiological and subjective correlates reflecting conditioned sexual response, and sexual memory formation. Hypothesis: We hypothesize that administration of DCS after a classical…
1) to identify the effect of manipulating the electrical synapses in the IO on motor learning in healthy individuals during cerebellar specific motor adaptation tasks. 2) to identify the effect of manipulating the subthreshold oscillations in the IO…
1. To assess the role of the DA and opioid systems in pain-avoidance learning.2. To examine the mechanisms via which DA and/or opioids contribute to pain-avoidance learning. Specifically, combining the levodopa and naltrexone manipulations with fMRI…
This aim of this study is to evaluate the secondary outcome measures including three to four year re-injury data.
Our primary objective is to investigate the effects of methylphenidate on language comprehension and creativity, and to link these effects with the effects of methylphenidate on working memory. Our secondary objective is to establish the relation…
The purpose of this study will be to examine the effect of ferrous fumarate or ferinject in patients after a caesarean section with a hemoglobin level between 5.0. and 7.0 mmol/L.The primary outcome measure will be the hemoglobin level at 3 and 6…
Posner spatial cueing task will be used to investigate electrophysiological differences in brain oscillatory lateralization during attentional shifts in children with and without ADHD. We hypothesize that the observed difference in the ability to…
In this study we focus on behavior in response to different infant signals, including crying as well as smiling. More specifically we investigate the behavioral differences of an individual towards different infants who are either perceived as happy…
Primary objective: To create diagnostic and treatment tools for navigation ability in stroke patients, that can be used in clinical practice.Secondary objective: To increase knowledge about the cognitive structure and neuroanatomical correlates of…
To investigate whether bowel relaxation, induced by administration of hyoscine N-butylbromide, improves the detection, removal and colllection of lcolonic polyps during colonoscopy
To compare the methods patients will be divided into two groups, a therapy group (receiving cTreatment) and a control group (receiving standard cryotherapy). Patients will be evaluated pre- and postoperatively, wherefore the following data are…
The main objective is to illuminate the effect of S 44121 (restores the Ca²+ release channel function by improving the rebinding of the channel-stabilizing subunit (calstabin)) versus placebo administered orally for a total of 12 weeks on MTWA in…
Fundamental research with the objective to gain more insight in empathic processes within people suffering from psychopathy. Goal is to evaluate if affective empathic can be temporarily altered (in terms of minutes).
The current study aims to further our understanding of the relationship between baseline measures - such as impulsivity, working memory and social support - and the effects of enhancing dopamine (via methylphenidate administration) across a wide…
The objective of the study is to investigate the effect of chewing gum with and without magnolia extract on the composition of dental plaque and saliva. In addition the influence of chewing gum on the wettability of the tooth surface will be studied…