35 results
Multiple rounds of S(+)-ketamine infusions will give more profound and prolonged pain relief compared to a single infusion of S(+)-ketamine.
Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.
Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…
Perioperative esmolol infusion titrated for heart rate control as an add-on to standard therapy including a long acting oral beta-blocker will improve heart rate control and decrease perioperative myocardial ischemia, without an increase in…
It is hypothesized that a preoperative oral antibiotic prophylaxis, that is administered in addition to perioperative intravenous prophylaxis, will lead to a reduction in postoperative would infections after colorectal surgery
Part 1 Single Ascending Dose (SAD) - To evaluate the safety and tolerability of a single oral dose of prodrug, ABX-002, in healthy adult subjects Part 2 Multiple Ascending Dose (MAD) -To evaluate the safety and tolerability of once daily oral…
Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…
Children with chronical abdominal pain and small intestinal bacterial overgrowth supplemented with probiotics will show less abdominal pain compared to placebo.
Predominantly sleeping in the non-supine position could improve oxygenation and thereby shorten the disease course in admitted COVID-19 patients.
The primary objective of the study ”STOP PAIN” is to compare the effect on migraine attack frequency of transcatheter device closure of atrial shunting with a non-closure group in migraine patients suffering severe migraine with aura.
1. A decrease in cocaine use over a three month period in participants who receive AAT training as opposed to VPT training. 2. A change in symptoms involving craving, the urge to use, withdrawals well as stated readiness to change in participants…
We recently found that memories can be weakened by applying electroconvulsive therapy (ECT) shortly after reactivation of a memory (Kroes et al., 2014). This suggests that reactivation of negative schemas just prior to ECT may also weaken those…
The study will investigate the effect of a synbiotic test product compared to a control product on the composition and metabolic activity of the gut microbiota of C-section delivered infants.
90-day treatment with a selected probiotics mixture can reconstitute the microbiome diversity after antibiotic treatment for community-acquired pneumonia.
Administration of fluoxetine during late brain development (adolescence), but not in adulthood, will result in abnormal outgrowth of the 5-HT system. This long-lasting disturbance of the 5-HT system may be visualized using MRI techniques and can…
Acute Rockwood type 3 AC-luxations will have a better function after operative treatment with the artroscopic TightRope technique than patients treated conservative.
We hypothesis that antiplatelet therapy adjunctive to rt-PA thrombolysis improves outcome by preventing re-occlusion in terms of three months clinical outcome.
The study objective is to show that Bifidobacterium animalis is effective in increasing defecation frequency after 3 weeks of product consumption in children with functional constipation.
Although current treatment programs for adolescents with substance use disorders show beneficial outcomes, post-treatment relapse rates remain high and leave room for further improvement. Patients with an addiction show neurocognitive deficits and…