56 results
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
Our hypothesis is that the efficacy of FMT in patients with active UC can be increased by: 1. Pretreatment with budesonide in patients with active UC, which may reduce inflammation prior to infusion of the donor feces solution. This reduced…
To investigate the effect of a three-week treatment with cannabidiol (CBD) on anxiety in patients with a primary brain tumor that have no active oncological treatment. Depression, fatigue and general quality of life are secondary outcome measures.…
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
Part 1 Single Ascending Dose (SAD) - To evaluate the safety and tolerability of a single oral dose of prodrug, ABX-002, in healthy adult subjects Part 2 Multiple Ascending Dose (MAD) -To evaluate the safety and tolerability of once daily oral…
By dosing Ampligen every other day intranasally, it is believed that SARS-CoV-2 can be inhibited at the point of entry, and thus will be much less likely to progress to a pulmonary infection, or moderate COVID-19 disease.
To reduce fatigue symptoms with the use of a bovine lactoferrin supplement in patients suffering from Long COVID.
To investigate the safety, tolerability and pharmacokinetics after multiple daily doses of YTX-7739
A direct patient feedback system can lead to earlier detection of pain and a more timely treatment resulting in improved patient reported outcomes on postoperative pain.
We hypothesize that treatment with Tapentadol will reduce the development of chronic postoperative pain by enhancing or maintaining CPM responses and possibly reducing central sensitization. We hypothesize that a 4-week treatment with Tapentadol…
Our research objectives are two-fold: First we investigate whether nocebo effects can be learned via electrical pain conditioning and verbal suggestions. We expect that participants in the nocebo group, but not the control group, will report higher…
The aim of this study is to prospectively assess the efficacy of LDN as induction therapy in CD.
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
Let µT denote the mean value of the composite IBS-SSS score under treatment with the active / GOS and µP denote the mean value of the composite IBS-SSS score under placebo, then the primary two-sided hypothesis to be tested is: • H0: µT - µP = 0 (i.…
• To assess effect of zolpidem compared to placebo on walking (adapt)ability in healthy elderly as measured by the Interactive Walkway. • To assess effect of suvorexant compared to placebo on walking (adapt)ability in healthy elderly as measured by…
The null hypothesis states there is no difference in effectiveness of the ESPB compared to placebo on early postoperative pain intensity measured with NRS in patients that underwent lumbar spine fusion surgery.
Co-ingesting keto-analogues of branched-chain AAs along with protein during HD attenuates HD-initiated muscle catabolism.
Primary To characterize systemic and local KLH-specific B and T cell responses by repeated KLH immunizations Secondary To characterize the molecular basis of the KLH-driven skin response (acute versus delayed response, Th1 versus Th2 response) To…
Previous studies with this compound (Roozekrans, 2014), confirmed the stimulatory effects on respiratory function under hypercapnic ventilatory conditions and with co-administration of an opioid. This study aims to evaluate the ventilatory response…