348 results
In the first of two substudies, we test the hypothesis that in healthy individuals without ELS, hydrocortisone will be effective in enhancing stress adaptation and extinction learning in an experimental model of exposure therapy, while it is not in…
Primary Objective To evaluate the safety and tolerability of topical XZ.700 in patients with mild to moderate atopic dermatitis Secondary Objectives To investigate the PD effects of XZ.700 in patients with mild to moderate atopic dermatitis To…
Post-donation iron supplementation will be an effective strategy to enhance the iron status recovery in whole blood donors with low ferritin levels.
Due to its ability to avoid preterm birth, the neurodevelopmental sequelae of preterm birth could also be prevented by progesterone. However, progesterone may also exert direct effects on the fetus’ developing brain.
Oral bisphosphonate supplementation or the MMR vaccine can be used as immune potentiators when simultaneously administered with BCG, to further amplify the BCG-induced trained immunity response and maximize potential protective effects against COVID…
We expect to see a greater decline in cue-induced craving after intervention in the active group than the control group.
The main objective of the study is to investigate if positional therapy during sleeping, using the LEFT device, reduces nighttime gastroesophageal reflux symptoms.
The hypothesis is that random assignment to C1-INH in patients with moderate and severe TBI will experience a reduction in ICP directed therapy intensity levels (TIL) compared to random assignment to placebo (difference of 2.2). Secondary, if…
We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status, which will eventually reduce the risk of coronary calcification.
We expect that metformin in combination with lifestyle interventions reduces Antipsychotic induced Weight Gain compared to placebo in combination with lifestyle interventions.
We hypothesize that BCG vaccination may reduce hospital admission and improve the clinical course of symptoms of elderly people during the SARS-CoV-2 outbreak.
2gr of Cefazolin is effective as prophylaxis for surgical site infections following implant removal below the level of the knee.
We hypothesize that the metabolic effects of acute infusion of acetate are different in insulin resistant subjects compared to lean subjects.
1) It is expected that the percentage of days abstinent will be higher in both training interventions compared to the sham ApBM with religion-adapted ApBM having the biggest effect-size in this comparison. Also, it is expected that participants with…
The pericapsular nerve group (PENG) block is superior to placebo 'sham' blocks in hip arthroplasty surgery in reducing patients pain scores (Numeric Rating Scale of 0 to 10), on the day of surgery
To investigate whether augmentation of one standardized exposure session for SAD with tVNS has beneficial effects compared to sham enhanced exposure by examining subjective anxiety during exposure. Subjective anxiety will be measured with ‘…
We expect to find differences between the intervention groups and control group (in favour of the intervention groups) on behaviour, quality of life, well-being and communication behaviour scores in nursing home residents with dementia and distress…
The objective of the study is to evaluate safety, tolerability, and pharmacokinetics (PK) of ALKS 6610 after single ascending oral doses in healthy adult subjects.
This study will investigate the potential of EDP1815 to modify the immune system through a Keyhole Limpet Haemocyanin (KLH) challenge. Furthermore, safety and tolerability of multiple oral doses of the monoclonal microbial EDP1815 will be assessed…
We hypothesize that GABA could improve glucose tolerance and cardiovascular health after long-term supplementation