48 results
The primary objectives are: 1) to determine the effect of bile acids on glucose uptake in brown adipose tissue; 2) to determine the effect of bile acids on whole body energy expenditure and 3) to determine the effect of bile acids on skeletal muscle…
STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…
To provide insight in the physiological significance and underlying mechanisms involved in the relation between gut microbiota, energy balance and insulin sensitivity in overweight men with impaired glucose homeostasis
The primary objectives are to investigate whether L-carnitine infusion may rescue lipid-induced insulin resistance and whether L-carnitine infusion is improving metabolic flexibility in the state of lipid-induced insulin resistance. Furthermore,…
This project consists of two related studies. The objective of part 1 is to investigate the effect of elevated plasma lactate levels that are sufficient to impair awareness of hypoglycemia on brain lactate concentrations during euglycemia and…
To explore the inflammatory changes of a PCSK-9 inhibitor compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus.
The current research proposal intends to study the therapeutic potential of moderate intermittent hypoxia (IH) exposure in subjects at high risk of developing type 2 diabetes, and aims to address the following key objectives:1) To investigate the…
PrimaryThe 3 months* effect of Vildagliptin on insulin synthesis and storage capacitySecondaryThe 3 months* effect of vildagliptin on- Glucose, insulin, C-peptide levels- Hormonal axes, most importantly GLP1 and GIP and Glucagon- Body weight, body…
Primary objectives:1. Is plasma aldosterone concentration associated with microvascular function, specifically insulin-mediated capillary recruitment, in obese subjects?2. Does mineralocorticoid receptor antagonism result in improvement of…
The purpose of the study is to investigate wether long-term resveratrol supplementation (6 months) leads to improved insulin sensitivity (estimated by Matsuda Index) in people with overweight/obesity. In addition we will investigate effects of…
To explore the inflammatory changes of dapagliflozin compared with placebo on postprandial lipemia and postprandial leukocyte activation, oxidative stress and endothelial function in men with type 2 diabetes mellitus using insulin.
The aim of the study is to investigate effects of dapagliflozin on potential mechanisms explaining improved insulin sensitivity in skeletal muscles.
Objectives: To investigate the effect of a daily sachet of probiotics on vitamin K status for 12 weeks vs placebo.
To test the hypothesis that metabolic inflexibility in pre-diabetic subjects and diabetic patients is due to a reduced capacity to form acetylcarnitines: We aim to investigate whether glucose intolerant subjects have a lower capacity to form acetyl-…
To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.
In this double blinded randomised controlled trial we aim to compare the effects of 4 grams of oral butyrate tablets once daily following autologous (own) faecal transplantation with post-RYBG donor faecal transplantation with placebo tablets, at…
Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…
We hypothesize, that during an oral glucose tolerance test, the OPS arterial flow measured sublingual will be comparable within the same subject, but different between young, elderly and type 2 diabetic patients. Objective is to quantify differences…
to measure peripheral insulin sensitivity and intramyocellular concentrations of different FA metabolites (ceramide, gangliosides, diacylglycerol and triacylglycerol) known to interfere with the insulin signalling cascade during infusion of…
The major research objective is to investigate 1) whether lowering cardiac and muscular lipid content will improve mitochondrial and cellular function in type 2 diabetic patients, and 2) whether this lipid lowering effect also improves uncoupling in…