239 results
Primary objectiveThe primary objective of this study is to compare the efficacy of ETN against placebo in improving symptoms of early non-radiographic axial SpA at 12 weeks when added to a background NSAID at the optimal anti-inflammatory dose.…
1. Is a home-based peripheral muscle training program (5BX) more effective in (a) increasing peak work rate and (b) patients* preferred occupational performance in patients with CF who are preconditioned by IMT?2. Which variables are indicators of…
STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…
To determine whether the use of epinephrine saline irrigation in therapeutic shoulder arthroscopy with need for subacromial procedures should significantly increase clarity of the view.
Investigate the value of percutaneous radiofrequency heat lesion, applied to the medial branch of the primary dorsal ramus; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-…
1. To assess the effect of odanacatib 50 mg once weekly versus placebo on lumbar spine BMD over 24 months.2. To assess the safety and tolerability of odanacatib 50 mg once weekly compared to placebo.
Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…
To assess the analgesic efficacy, safety, and tolerability of once daily orally administered GRT6005 in a total of 3 fixed doses (i.e., 200 µg, 400 µg, and 600 µg GRT6005) compared to placebo in subjects with moderate to severe chronic LBP.
The primary objective is to assess the efficacy of sirukumab as measured by the reduction of the signs and symptoms of RA in subjects with active RA who are refractory to an anti-TNF Alpha agent. The secondary objectives are to assess the following…
The purpose of the study is compare the effect excentric exercise in combination with electric shockwave therapy with excentric exercise and sham shockwave therapy. This is measured with the VISA-P score in short term, middle term and long term…
Improvement of the functional recovery of patients with a hipfracture and the prevention of re-surgery.
Determining the outcome of reversed and antegrade LIA in THA with ASI by analysing postoperative pain with the 100 mm Visual Analogue Scale (NRS), length of hospital stay, the amount of postoperative consumption of opioid pain medication as well as…
measuring the efficicy of the combination of green lipped mussel, curcumin and ribus nigrum (supplement Synofit) on quality of life and pain in patients with osteoarthritis of the knee
Please refer to protocol, section 1.2 "Rationale"
The primary objective is to test the hypothesis that once daily tadalafil administered orally for 48 weeks lessens the decline in ambulatory ability as measured by the 6MWD compared to placebo in boys with Duchenne muscular dystrophy (DMD). Two…
Primary:To evaluate the efficacy and safety of anakinra in the treatment of pain in patients with an acute gout attack during 3 days and subsequently assess the effect of anakinra treatment for 21 days in the prevention of recurrent gout attacks.…
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people. In addition, we aim to study the underlying mechanisms of creatine and disuse…
1.1 Primary ObjectivesDuring 12 weeks of treatment in subjects with active RA on stable DMARD therapy:• To evaluate the efficacy of VX-509 across a range of doses• To evaluate the early effect of VX-509 administration on joint structures as assessed…
The primary objective of the study is to determine whether baricitinib 4 mg QD is superior toplacebo in the treatment of patients with moderately to severely active RA who have had an inadequate response to a TNF inhibitor, despite ongoing treatment…
The primary objective of the study is to determine whether baricitinib is superior to placebo in the treatment of patients with moderately to severely active rheumatoid arthritis (RA) despite methotrexate treatment (ie, inadequate response to…