22 results
Primary hypotheses The primary hypothesis of the present study is that included patients who receive continuous or intermittent oxygen and bilevel positive pressure ventilation during fixed work rate treadmill exercise tests have shorter recovery…
-We expect that the youth who receive an active CBM training on top of care-as-usual show a greater reduction in cannabis or alcohol misuse at follow up when compared their general population peers. -We expect that CBM training works by reducing…
Approximately 1/3 of persons with IGT develops type 2 diabetes mellitus in 5-10 years time. Acarbose is an alpha-glucosidase inhibitor decreasing post-prandial glucose levels, without the risk of hypoglycemia. The prevention of diabetes with…
Assess the safety and tolerability of single ascending IV bolus doses of ABP-700
•To investigate the safety and tolerability of multiple ascending oral doses of DNL104 in healthy subjects •To characterize the pharmacokinetics (PK) of DNL104 in plasma and measure the trough concentrations of DNL104 in CSF. •To Explore the…
Modulation of phosphate intake can affect the antiproteinuric efficacy of RAAS-blockade therapy in CKD patients
The implementation of antimicrobial coatings in health care results in an improved hygienic environment to support patient recovery and lowers the risk of a health care associated infection.
We hypothesize that Iberogast reduces heartburn in patients with functional dyspepsia through an effect on both oesophageal hypersensitivity to acid and on the incidence of reflux episodes.
A niche is a defect that can develop at the site a caesarean section scar. A niche can cause complaints of abnormal uterine blood loss, dysmenorrhea, chronic pelvic pain and is related to infertility. Several innovative surgical therapies have been…
We hypothesize that tACS can enhance brain synchronization between frontal and parietal regions, thereby improving cognitive functioning in MS patients.
We hypothesized that methylphenidate will improve certain aspects of language comprehension and creativity.
It is hypothesized that chicken eggshell membrane is effective in the regeneration of cartilage and/or immunomodulation (oral tolerance), and as such positively affects pain and stiffness in joints commonly affected in arthritis
We expect that supplementation with vitamin K will attenuated or reduce ongoing calcification and will significantly reduce dp-ucMGP in patients with type 2 diabetes.
The main hyothesis of the experiments is that a dual action antidepressant (duloxetine) modulates functions in specific brain areas involved in the processing bias of emotional stimuli in the context of neutral versus depressed mood.
Hypothesis 1: We expect to find an approach bias in forensic sexual offenders and in sexual addicts. Hypothesis 2: The proposed intervention will cause a decline in approach bias in forenisc sexual offenders and sexual addicts, compared to the…
To determine the role of 5-HT2 and 5-HT1A receptors in learning and memory. It is expected that: 1. An acute dose of MDMA will produce impairments on laboratory measures of learning and memory; 2. MDMA-induced memory impairment will be reversed…
1.We expect participants in the experimental condition to show a reduced gmbling behaviour 2. We expect participants in the experimental condition to show a decrease in approach bias towards gambling cues, and weaker approach implicit associations…
Stimulation of the right DLPFC of alcohol dependent patients will decrease self-reported craving and recude relapse rates. Furthermore it will increase behavioral control and normalize brain activation patterns.
Varenicline reduces craving to cocaine and/or impulsivity in human cocaine users.
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…