314 results
Reversibility of oral direct factor Xa inhibitors rivaroxaban and apixaban will be the same when a lower dosage of prothrombin complex concentrate (Cofact®) is used. Infusion with doses of 37.5 or 25 units/kg of PCC would be able to reverse the…
We will develop a bi-daily low-dose metronomic treatment schedule with paclitaxel in a convenient oral formulation and test whether this therapy has significant anti-angiogenic and anti-tumor activity.
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a prevalence of 1-2% in the general population, increasing with age. It is associated with a 5-fold increased risk of stroke if untreated. While anticoagulant agents are effective…
To determine whether sunitinib rechallenge in patients with mRCC, who had benefit (defined as stable disease for at least 6 months) from prior treatment with sunitinib and who progressed on both sunitinib and second-line therapy (or were without…
Reproducible test-retest assessment of [18F]FDG PET.
High-dose, weekly erlotinib is a therapeutic option for EGFR-mutated NSCLC patients with leptomeningeal metastases while on EGFR-TKI therapy. In one of the patients treated with this dose schedule not only the leptomeningeal metastases showed…
Yellow fever specific T cells are present in 70% of patients using immunosuppressive medication versus 99% of healthy volunteers.
8 weeks after the PRF treatment we expect that the electric quantitative sensory testing (eQST) values are higher compared to the eQST values before the PRF treatment. This means that patients can tolerate a higher stimulation threshold. The…
Background: Injury rate and injury severity of elderly cyclists due to self-induced cycle accidents increase with age. Starting at the age of 55 years, injury risk increases with a factor 4 at the age of 75 years. Injury mechanisms such as slippery…
Fluorescent near-infrared imaging can be used to identify the ureters using a low dose methylene blue.
It is hypothesized that participants who received information about social modeling effects in the intervention group consume less (snack) food compared to participants in the control group.
Combination therapy with telaprevir/ ribavirin is as effective as the current standard of care with peginterferon-alfa/ ribavirin for the treatment of acute Hepatitis C in HIV-infected individuals.
1. That adherence to the WHO recommendations (2003) for early child feeding among low-income Quetzaltenango mothers, specifically exclusive breastfeeding up to 6 months, is associated with higher growth attainment and greater disease resistance; 2.…
Chronic cold exposure will increase: 1. Basal metabolism and facultative thermogenesis; 2. Brown adipose tissue activity and volume; 3. Skeletal muscle mitochondrial uncoupling and result in BRITE cell recruitment.
Intra-operative evaluation of efficacy and safety of a new lead for steering Deep Brain Stimulation.
Primary Hypothesis: 1. Sapiens lead is able to provide stimulation to the brain safely and elicit equivalent effects as commercial DBS systems. Secondary Hypotheses: 1. Steering can modulate the thresholds of stimulation-induced effects; 2. The…
There will be a relation between the level lidocaine in newborn, the level in mother and drug-delivery interval.
Vaginal prolapse surgery is intended to restore abnormal pelvic floor function by restoring anatomical abnormalities of the vagina and its surrounding visceral organs. The surgical trauma that occurs during such correction may result in damage to…
Increased local insulin supplementation can reverse the blunted postprandial muscle protein synthetic response in the elderly, whereas local insulin supplementation does not affect the postprandial muscle protein synthetic response in the young.
Fluorescent near-infrared imaging can accurately detect breast cancer using Methylene Blue.