349 results
The present study is aimed at investigating cognitive underpinnings of anxiety, by focusing on working memory abilities in anxious individuals. A therapeutic intervention targeting working memory deficits will be tested in patients with anxiety…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in first episode psychosis patients, i.e. at onset of illness. We seek to assess whether deficits in M1…
Primary ObjectiveThe primary objective of this study is to assess whether the antidepressant response to IV ketamine can be maintained by minocycline compared to placebo.Secondary ObjectivesThe secondary objectives of this study are:* To investigate…
Zie K1. NL
Primary objectiveTo assess whether the use of alimemazine improves symptoms of allergic diseases and ADHD, as scored by the parents using standardized questionnaires (Sample Snap IV rating scales)
To investigate the dynamic relationship between hemodynamic responses to different levels of acute SERT occupancy induced by different doses of the reuptake inhibitor (SSRI) citalopram with 5-HT phMRI, as compared to [123I]FP-CIT SPECT imaging.…
We aim to assess the effect of high-dose vitamin D supplementation on non-specific musculoskeletal complaints in non-Western vitamin D-deficient immigrants and to determine whether improvement of mood is associated with this effect.
1. To demonstrate the clinical efficacy of leuco-methylthioninium bis(hydromethanesulfonate) (also known as LMTM,TRx0237) in mild Alzheimer*s disease as assessed by change from baseline on:• Alzheimer*s Disease Assessment Scale - Cognitive Subscale…
Primary Objective• To validate the existing demarcation formula (consisting of psychometric and biological markers) which predicts the sensitivity to Lybrido or Lybridos in women with female sexual interest/arousal disorder (FSIAD with or without…
The primary aim of this study is to measure the effect of light therapy on mood in depressed Parkinson patients. In addition, we measure the effect of light therapy on sleep, motor functions, circadian rhythms and quality of life.
Our objective is to assess the effect of TRP depletion on mood and behavior in PD patients treated with STN DBS. By doing, this, we hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of STN DBS.…
Objective: This study will investigate if AIM can be trained among people with chronic anger management processes. According to the AIM model, repeating avoidance responses to threatening stimuli may reduce aggressive impulses within this population…
Primary objectives:To determine the exposure-response relationship of EVP-6124 over a range of plasma concentrations in a scopolamine-induced cognitive deficit model in healthy elderly subjects.Secundary objectives:To determine the exposure-response…
Investigation of the effect of interpretive bias modification on anxiety levels in dental phobia. If CBM-I indeed has positive effects in the treatment of dental phobia, it could be integrated in the treatment-as-usual as an additional intervention…
The objective of this study is to investigate whether subjects who have taken esketamine, will be able to drive a car as soon as their cognitive function has been restored. The residual effects on driving performance will be compared to placebo.…
Primary objective:- To identify the psychological mechanisms via which testosterone modulates value-based decision making, such as testosterone's effects on risk-taking levels, impulsivity and self-control in intertemporal choice, and social…
2.1 Primary Objectives• Evaluate the safety and tolerability of 2 fixed doses of FRM-0334 (300 and 500 mg daily in 2 sequential periods) over 28 days in subjects with prodromal to moderate FTD-GRN• Assess the PD effects of FRM-0334 on the change…
This study will investigate the counter impulse hypothesis. According to the counter-impulse hypothesis, avoidance motivation counters aggressive impulses. Consequently, this regulatory impact should be especially effective when people*s aggressive…
Main objective Part 1: To assess the safety and tolerability of RO6799477 after multiple ascending oral doses in healthy volunteers.Part 2: To assess the safety and tolerability of RO6799477 after multiple oral doses in patients with type 2 diabetes…
To evaluate the effect of tDCS (anodal and cathodal) to the right dorso-lateral prefrontal cortex on the consolidation of fear extinction memory in healthy volunteers as compared to sham tDCS (control) as measured by psychophysiological measures (…