52 results
The study objective of the trial was to test the hypothesis that treatment with mepolizumab only affects inflammatory eosinophils whereas treatment with benralizumab affects both inflammatory and resident eosinophils.
"The primary objective of this study is to evaluate the fixation and migration patterns of the Persona Partial Knee (Zimmer Biomet, Warsaw, IN) in vivo, using model-based radiostereophotogrammetric (mRSA) analysis. The secondary objective is to…
To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
We expect that all three treatments are effective. However, the posterior tension night splint might be earlier effective compared to the other treatments.
HFpEF patients have impaired peripheral microvascular function compared to controls without HFpEF, with correction for important confounders of microvascular function.
Tones vs. neutral self-voice (EEG experiment 1 in Session 3; Pinheiro et al., 2018): a) no effect of HP on N100 suppression for self- and externally generated tones as we would expect alterations in sensory feedback only with regards to one’s own…
Vitamin C deficiency may play a role in the symptoms of patients with chronic kidney failure and eventually renal replacement therapy
We hypothesized that intensive GDM treatment according to the new (2013) GDM criteria would result in a reduction in infants with birth weight >90th centile (large for gestational age, LGA), in comparison to treatment according to the old…
We hypothezise that patients with a primary tumor expressing ER and lacking HER2 but with CTCs expressing HER2 have a worse response on hormonal therapy.
paracetamol can be used to determine plasma volume
The quality of life of adult patients with NMD can be enhanced by providing capability care in comparison to usual care.
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery
The G7 BiSpherical acetabular system and the GTS femoral stem will have acceptable migration patterns at the two-year follow-up mark (G7 BiSpherical acetabular system) and at six months (GTS femoral stem)
there exist intra & inter patient variability of 17β-HSD-1 and other enzymes involved in the local generation of estrogens
Action research in which the intervention will be developped trough short-cylce evaluation rounds by the research team together with an expert panel. The initital intervention has been designed based on scientific literature review, practical…
The primary objective of this study is to evaluate the effect of surgical correction of pes equinovarus deformity compared to conservative treatment on personalized goal attainment. In addition, we will evaluate the effect of surgical correction of…
The primary objective of this study is to determine patient perspective of and satisfaction with follow-up type and frequency after THA and TKA. Therefore, we will send surveys to patients who had a THA or TKA between 1 and 15 years ago.
To prospectively study if patients carrying clinically relevant DPYD variants (DPYD*2A, c.2846A>T, c.1236G>A/HapB3, c.1679T>G) are more at risk for developing moderate/severe vesicles or bullae with 5-FU cream.
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals