248 results
We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10. This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
Patients with a BMI > 30 kg/m2 in the ICU have a higher incidence of pressure ulcers and wound infections in the ICU compared with patients with a BMI 18-25kg/m2. They develop them sooner during admittance and the severity and time to…
The aim of the study is to determine whether cardiac output measurements obtained using APCO are comparable with those obtained using transpulmonary (advanced FloTrac software) and intermitted bolus thermodilution cardiac output in critical ill…
The quality of human milk shows an association with the women's diet and lifestyle.
We developed an MRA with integrated accelerometer with which we plan to measure the therapy-effect of the MRA, the compliance and the position of the head of the patient.
Dietary inorganic nitrate supplementation will decrease O2 cost of exercise in patients with mitochondrial myopathy.
Based on the human milk composition, Nutricia Research has developed a new infant formula with a new fat blend, more similar to that of human milk. This new formula is currently being studied for safety and its effects on growth. The comparator used…
HCQ causes both autophagy inhibition and chromatin modification, thereby (re)sensitizing tumor cells to EGFR TKIs, hypothetically increasing response rates after one week.
There will be a relation between the level lidocaine in newborn, the level in mother and drug-delivery interval.
We will develop a bi-daily low-dose metronomic treatment schedule with paclitaxel in a convenient oral formulation and test whether this therapy has significant anti-angiogenic and anti-tumor activity.
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a prevalence of 1-2% in the general population, increasing with age. It is associated with a 5-fold increased risk of stroke if untreated. While anticoagulant agents are effective…
To determine whether sunitinib rechallenge in patients with mRCC, who had benefit (defined as stable disease for at least 6 months) from prior treatment with sunitinib and who progressed on both sunitinib and second-line therapy (or were without…
Reproducible test-retest assessment of [18F]FDG PET.
The hypothesis is that incorporation of this technique into existing medical devices (e.g. biopsy needle) would enlarge the accuracy and reliability of these devices.
One area where decision making is complex is in the treatment of stage I non-small cell lung cancer (NSCLC) where the two available options differ greatly. These options are surgical resection and stereotactic ablative radiotherapy (SABR). In a…
Cognitive-behavioral therapy and exercise training will improve fatigue in Sjögren’s syndrome and non-Sjögren’s sicca syndrome.
Despite good results of primary total knee arthroplasty (TKA) the number of revision total knee arthroplasties (rTKAs) is rising and a further increase is predicted. rTKA is a more complicated surgical procedure compared to primary TKA and leads to…
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.