2642 results
Primary objectives:To characterize the pharmacokinetics of the 300 mg trientine capsule with a fast dissolution profile.To assess the effect of dissolution rate on the pharmacokinetics of trientine.To assess the effect of food on the…
To investigate the safety, tolerability and efficacy of STR-324 infusions in healthy subjects.Primary objective (Parts 1 and 2)* To assess and characterise the safety and the tolerability of STR-324, over a 4-hour (Part 1) and a 48-h infusion (Part…
The effect of pelvic floor physiotherapy with biofeedback in patients with anal fissure and pelvic floor dysfunction.
Primary* Evaluate the effects of BMS-986231 on the left ventricular (LV) systolic function by stroke volume index (SVI) assessed by echocardiography compared to placebo. Secondary* Evaluate the effects of BMS-986231 on the left ventricular (LV)…
To study and evaluate the plasma concentration-time curves in health young women of free EPA and DHA, as well as those present in a fish oil food supplement (predominantly esterified to glycerol and/or as ethyl-esters) of their esters, following an…
In short it is widely accepted that EMDR is effective in treating PTSD. EMDR however is not commonly used in treating PTSD patients when there is a comorbid BPD, even though it has been proven that PTSD can be successfully treated when people suffer…
This study's objective is to assess the bioavailability of phosphorus after oral intake of a new hypoallergenic infant formula compared to the bioavailability of phosphorus after oral intake of the current hypoallergenic infant formula.
To examine whether a short or longer period on a ketogenic diet leads to an altered immune response after exercise.
We aim to study what the mean change in graft flow rate is when the cardiac output is increased with 10% and what the mean change in graft flow rate is, when the blood pressure is increased with 10% to enable further research to establish whether an…
The primary objective of this study is to investigate if the addition of bovine milk fat to an infant-formula product increases the diet-induced thermogenesis. Secondary objectives are to investigate if the addition of bovine milk fat in an infant…
The purpose of the study is to investigate how quickly and to what extent 2 different production batches of alpelisib (FMI and FMIopt) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…
The primary objective of the study is to prospectively confirm the safety and effectiveness profile of Coil treatment in consideration of the findings of previous Randomized Controlled Trials.Secondary objectives are determination of responder rates…
Primary Objective: The primary objective is to show that L-theanine has beneficial anxiolytic in healthy individuals. With the current experiment setup that entails the following effects of L-theanine compared to placebo:• Reduced startle effect on…
The primary objective of the study is to determine whether TAK-653, in comparison to placebo, increases CNS excitability, assessed with TMS-evoked MEP in healthy subjects.Next to that, the study has the following goals: - To determine whether TAK-…
The primary objective is to determine whether a high-fat meal can induce a persistent pro-inflammatory monocyte phenotype, characterized by an increased cytokine production capacity upon ex vivo stimulation. Secondary objectives are metabolic and…
The purpose of this study is to investigate if there is a difference in the injection site pain experience after an injection under the skin (subcutaneous) with 2 different products, semaglutide and dulaglutide, in healthy volunteers. The 2 products…
- To assess the pharmacokinetic profile of cysteamine base after single dose administration of the new sustained-release cysteamine bitartrate (PO-001) to healthy volunteers, in comparison with Cystagon® and Procysbi®.- To collect safety/…
Stage 1* To assess the safety and tolerability of single-ascending-dose levels of IW-6463 when administered to healthy subjectsStage 2* To assess the safety and tolerability of multiple-ascending-dose levels of IW-6463 when administered to healthy…
To examine and compare the effects of vaporized medicinal grade cannabis containing known concentrations and doses of the cannabinoids THC and CBD on on-road driving performance and cognitive function.
To compare the functional mobility of transfemoral amputation or knee exarticulation patients when using the ReMotion Knee and their current prosthetic knee. An additional aim is to examine the influence of the patient*s mobility level on the…