2642 results
Objectives: The primary objectives are: to determine if there is a perceivable difference between plain and FAAA-enriched versions of selected food products and describe sensory and/or hedonic differences between them; to assess the dependency of…
Primary objective:To assess the bioequivalence of single-dose velpatasvir administered as a fixed-dose combination of sofosbuvir/velpatasvir (SOF/VEL; Epclusa®) when given with cola + omeprazole 40mg (test 1/trt A) compared to velpatasvir…
Primary:In 1L subjects with metastatic squamous non-small cell lung cancer (NSCLC) receiving investigator*s choice of standard of care chemotherapy (i.e. carboplatin and a taxane):1. Evaluate progression free survival (PFS) per RECIST 1.1 as…
To study gastric emptying of breastmilk and infant formula and to see whether gastric emulsion stability differs between breastmilk and infant formula.
To demonstrate whether hydrochlorothiazide or metformin can diminish aquaresis in patients with ADPKD who are treated with tolvaptan as measured by 24-hour urine volume.
Primary objective: - To measure infraslow EEG changes during stress response in healthy subjects.Secondary objective(s):- To investigate if cortisol levels relate to ISA.- To explore ISA activity as a potential biomarker for stress.- To formulate…
Part APrimary objective:To determine the equivalent dose of pazopanib when taken with a continental breakfast compared to 800 mg in fasted state.Secondary objective:To monitor the occurrence of adverse events of pazopanib with and without food…
Primary objectivesPhase I:To determine the recommended phase 2 dose (RP2D) of the dacomitinib-PD-0325901 combination in patients with KRASm NSCLC Phase II:To determine the progression free survival of the dacomitinib/PD-0325901 combination compared…
The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…
The purpose of this study is to investigate the effect size in order to perform a power calculation for calculating a sample size for a powered RCT
Main objectives: The main aim of this study is twofold. We aim to (1) investigate whether rivastigmine can be used as a novel treatment to reduce ECT-induced interictal delirium and (2) to gain further insight into differences in determinants…
The effects of macronutrients on postprandial vascular function in overweight and slightly obese men
The primary objective of the proposed study is to evaluate the effect of the three macronutrients on postprandial vascular function, assessed by brachial artery flow-mediated vasodilation (FMD), in overweight and slightly obese male volunteers.…
The main objective of this study is to investigate the underlying mechanisms responsible for insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the…
To evaluate postprandial amino acid kinetics in blood, after consumption of (*10 g protein per 100 ml) of different types of dairy proteins (in varying combinations) in small volumes, in an older population
The primary objective of the proposed study is to evaluate the effect of the high dose or L-arginine (3.0 gram) and a lower dose of L-arginine (1.5 gram) compared with a placebo supplement on postprandial vascular function, assessed by brachial…
The purpose of this study is to investigate how quickly and to what extent two 25 mg prolonged release tapentadol tablets are absorbed and eliminated from the body (this is called pharmacokinetics) when compared to one 50 mg prolonged release…
To evaluate the utility of the WATS system, as a potential substitute for the random sampling method that is currently recommended as an adjunct to targeted biopsy
The first goal of the present research proposal is to investigate whether single session COMET imagery procedures, relative to no intervention control, increase the ease of recollection, the specificity, vividness and positive affectivity of…
The purpose of this study is to investigate how safe the new compound JHL1922 is when it is administered to healthy subjects. JHL1922 has not been administered to humans before, but it has been previously tested in the laboratory. In this study, the…
To study the effect of TRH on opioid-induced respiratory depression in healthy volunteers.