2642 results
Primary: * To assess the change baseline in 24-hr proteinuria with dapagliflozin for six weeks relative to placebo treatment in patients with non-diabetic kidney disease and proteinuria > 500 mg/day on stable ACEi or ARB treatment. Secondary…
To verify whether the emotional valence of the distracting task will affect the effects of the dual tasking procedure in a help seeking PTSS population.
To demonstrate superiority in peak bronchodilator effect of QVM149 at a dose of 150/50/160 *g o.d. and 150/50/80 *g o.d. compared to a FDC ofsalmeterol/fluticasone at a dose of 50/500 *g b.i.d. after 3 weeks of treatment in patients with asthma.
To examine the effects of a treatment that consists of different natural ingredients on cognitive performance in…
The primary objective is to explore the efficacy of nintedanib (as measured by progression free survival) as second line therapy for patients with either differentiated or medullary thyroid cancer progressing after first line therapy.
There are three aims in this project: 1. To investigate how the functional interaction between the locus coeruleus and other brain areas, in particular the medial temporal lobe areas, during memory processes (encoding, consolidation and retrieval)…
Our primary objective is to test the hypothesis that there is an association between high CPS at baseline and a low relative effect from subacromial anaesthetics (as compared to subacromial placebo). The increased pain perceived by these patients…
The primary objective is to evaluate the effect of bright light on postprandial blood glucose metabolism in obese subjects with impaired fasting glucose, impaired glucose tolerance, decreased insulin sensitivity or increased Hb1Ac. Exploratory…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…
The Primary objective is to confirm the maintenance of vigilance with SENS-111.Secondary objectives are:* to confirm the maintenance of working memory, and cognitive function; * to confirm the pharmacodynamics effect of SENS-111 on symptoms…
We hypothesize that the toxic potency of UFP from air traffic is comparable to road traffic after inhalation by healthy humans. Therefore, we aim to:* Identify acute effects of short-term inhalation of ultrafine particles right next to Amsterdam…
To develop a second VRelax prototype for reducing impact of stress and test it in patients with depressive, bipolar, anxiety and psychotic disorders. User experiences and immediate effects on subjective stress and arousal will be investigated and…
Objective: To assess the degree of digestibility and protection of the epithelial barrier of two alternative protein concentrates from corn and bovine plasma and of the commonly consumed benchmark protein whey. These outcomes will also be used to…
The present study explores the dose-response relationship in LSD-induced subjective and cognitive effects using small doses of LSD (5, 10, and 20 µg) compared to placebo.
The effect of a combination of orange- and pomegranate actives on physical fitness in elderly people
The primary objective of this study is to determine the effect of daily supplementation of a combined orange- and pomegranate extract for a period of 4 weeks on physical fitness compared to placebo.
Primary objective is to evaluate the area under the plasma concentration-time curve (AUC) of capecitabine alone, compared to capecitabine used with esomeprazole and compared to capacitabine used with esomeprazole and the acid beverage Coca-Cola in…
The aim of the study is to investigate effects of dapagliflozin on potential mechanisms explaining improved insulin sensitivity in skeletal muscles.
This study aims to determine the digestibility of AAs in two protein sources in men and women with normally functioning ileostomies.
To assess the effect of Ziverel on esophageal sensitivity to acid, mucosal barrier function and reflux symptoms in patients with PPI-refractory reflux symptoms.
This study aims at investigating potential relevant QT effects of clazosentan at supra therapeutic doses in healthy male and female subjects using a concentration/response analysis approach in compliance with the ICH E14 guidance [FDA 2017].Primary…