47 results
To compare the effects on glycemic control, patient reported outcomes (PRO) and experiences (PRE) of rt-CGM with FGM in a real-life outpatient setting among persons with T1D.
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
The primary objective is to compare the pharmacological profile of the magistral form of dexamphetamine sulphate to the pharmacological profile of the brand-name form of dexamphetamine (Tentin©) in adult patients diagnosed with attention deficit…
The objective of this first-in-human study is to evaluate the safety, feasibility and efficacy of Re-Cellularization via Electroporation Therapy (ReCET) by the (Endogenex system) combined with (GLP-1 receptor agonist) in subjects with insulin…
Sodium-glucose cotransporter 2 (SGLT2) inhibitors lead to a lowering of blood pressure and confer cardiovascular and renal protection in many, but not all people with type 2 diabetes (T2D), possibly due to a difference in sodium intake. with this…
The objective of this study is to evaluate the safety and efficacy of the AccuCinch Ventricular Restoration System in patients with symptomaticheart failure with reduced ejection fraction (HFrEF).
Main research question and primary objective: What is the effect of exposure to high vs. neutral temperature (32* C vs. 25* C) in combination with high vs. low humidity (30 %RH vs. 70 %RH) for 8 hours on cognitive performance?Secondary research…
The objective of this study is to investigate the feasibility of using MT and CEST MRI for in vivo monitoring of gastric protein digestion (coagulation and breakdown). This will be done by studying the effect of heating on gastric protein…
Primary objectivesTo study whether Geranyl-Geranyl Acetone (GGA) reduces left ventricular (LV) diastolic dysfunction in patients with HFpEF compared to placebo (and to assess/confirm its effectiveness and safety in patients with HFpEF)Secondary…
Certain drugs are administered by using an inhaler (puffs). An inhaler may contain propellant to get the right amount of the medicine into the lungs in the right way. Some of the propellants used in inhalers are greenhouse gasses and are therefore…
The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise.
This study consists of the following objections:- To evaluate feasibility, safety, and efficacy of endoscopic DMR Treatment Paradigm 1 (compared to sham)- To evaluate feasibility, safety, and efficacy of re-treatment with DMR at 24 weeks (compared…
to assess the effects of BPA on quality of life and exercise capacity in a group of symptomatic CTEPD patients without PH with incomplete recovery after three month of rehabilitation.
The aim of this project is to assess the acute effects of the N-methyl-D-aspartate receptor antagonist S(+)-Ketamine compared to placebo on body and self-perception, using cognitive experimental tasks and EEG in healthy volunteers.
(Also see METC- protocol)Primary Objective:To investigate the effectiveness of the SPACE treatment to improve family accommodation and OCD symptoms.Secondary Objective: To explore mechanisms of change (in OCD symptoms) for the effectiveness of the…
To explore the effect of a LCHF diet on clinical symptoms and gut microbiome in MD patients due to the m.3243A>G mutation in mitochondrial DNA.
The aim of the present study is to investigate the effect of a citrus extract rich in the flavonoids hesperidin and naringin on sleep quality and mental wellbeing in healthy subjects with sleep (minor) disturbance.
Primary objectiveThe primary objective is to determine whether 3-MMC can be safely administered in healthy volunteers in doses up to 100 mg. Participants will be monitored by a medical doctor and vital signs, laboratory safety and side effects will…
In this research study we want to assess whether eating potato-rich food products are a good dietary strategy to recovery both liver and muscle glycogen stores following exhaustive exercise in healthy young endurance trained males over 24 hours.
The primary objective is to estimate differences in postprandial plasma total essential amino acids (TEAA) profiles after protein consumption, determined by appearance (profiling, iAUC and peak Cmax), between pea, faba, casein, and whey in blood of…